Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Ye, Dang Wu, Jinwen Shen, Pin Wu, C. Ni, J. Chen, J. Zhao, Tao Zhang, Xiaolei Wang, Jian Huang (2012)
Enrichment of colorectal cancer stem cells through epithelial-mesenchymal transition via CDH1 knockdown.Molecular medicine reports, 6 3
C. Rosser, S. Goodison (2010)
CD24, a promising biomarker in NSCLC.Biomarkers in medicine, 4 4
P. Bradbury, F. Shepherd (2007)
Chemotherapy and surgery for operable NSCLCThe Lancet, 369
J. Cos, M. González, María Montero, María Calvo, M. Vicente, M. Valle (2009)
Non-small cell lung cancer and silent brain metastasis. Survival and prognostic factors.Lung cancer, 63 1
H. Menssen, E. Bertelmann, S. Bartelt, R. Schmidt, G. Pecher, K. Schramm, E. Thiel (2000)
Wilms' tumor gene (WT1) expression in lung cancer, colon cancer and glioblastoma cell lines compared to freshly isolated tumor specimensJournal of Cancer Research and Clinical Oncology, 126
P. Maione, C. Gridelli, T. Troiani, F. Ciardiello (2006)
Combining targeted therapies and drugs with multiple targets in the treatment of NSCLC.The oncologist, 11 3
Y. Oji, S. Miyoshi, E. Takahashi, S. Koga, Y. Nakano, Y. Shintani, H. Hirabayashi, A. Matsumura, K. Iuchi, K. Itô, Y. Kishimoto, A. Tsuboi, K. Ikegame, N. Hosen, Y. Oka, H. Ogawa, H. Maeda, S. Hayashi, I. Kawase, H. Sugiyama (2004)
Absence of mutations in the Wilms' tumor gene wt1 in de novo non-small cell lung cancers.Neoplasma, 51 1
Jiekai Chen, Qingkai Han, D. Pei (2012)
EMT and MET as paradigms for cell fate switching.Journal of molecular cell biology, 4 2
A. Tsao, Suyu Liu, J. Lee, C. Alden, G. Blumenschein, R. Herbst, Suzanne Davis, Edward Kim, S. Lippman, D. Stewart, X. Tang, I. Wistuba, W. Hong (2012)
Clinical Outcomes and Biomarker Profiles of Elderly Pretreated NSCLC Patients from the BATTLE TrialJournal of Thoracic Oncology, 7
H. Pinheiro, J. Carvalho, P. Oliveira, D. Ferreira, M. Pinto, H. Osorio, D. Licastro, Renata Bordeira-Carriço, P. Jordan, D. Lazarević, R. Sanges, E. Stupka, D. Huntsman, R. Seruca, Carla Oliveira (2012)
Transcription initiation arising from E-cadherin/CDH1 intron2: a novel protein isoform that increases gastric cancer cell invasion and angiogenesis.Human molecular genetics, 21 19
S. Dubey, J. Schiller (2005)
Three emerging new drugs for NSCLC: pemetrexed, bortezomib, and cetuximab.The oncologist, 10 4
Geiger (1992)
CadherinsAnnu Rev Cell Biol, 8
A. Knudson, A. Knudson, L. Strong (1972)
Mutation and cancer: a model for Wilms' tumor of the kidney.Journal of the National Cancer Institute, 48 2
Haijun Zhang, F. Meng, Gang Liu, Bin Zhang, Jun Zhu, Feng Wu, S. Ethier, F. Miller, Guojun Wu (2011)
Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis.Cancer research, 71 4
M. Takeichi (1993)
Cadherins in cancer: implications for invasion and metastasis.Current opinion in cell biology, 5 5
D. Cilloni, E. Gottardi, D. Micheli, Anna Serra, G. Volpe, F. Messa, G. Rege‐Cambrin, A. Guerrasio, M. Divona, F. Coco, G. Saglio (2002)
Quantitative assessment of WT1 expression by real time quantitative PCR may be a useful tool for monitoring minimal residual disease in acute leukemia patientsLeukemia, 16
Peng Kuang, Caicun Zhou, Xue-Fei Li, S. Ren, Bing Li, Yongsheng Wang, Jiayu Li, Liang Tang, Jie Zhang, Yin-min Zhao (2012)
Proteomics-based identification of secreted protein dihydrodiol dehydrogenase 2 as a potential biomarker for predicting cisplatin efficacy in advanced NSCLC patients.Lung cancer, 77 2
E. Miller-Hodges, P. Hohenstein (2012)
WT1 in disease: shifting the epithelial–mesenchymal balanceThe Journal of Pathology, 226
N. Dubrawsky (1989)
Cancer statisticsCA: A Cancer Journal for Clinicians, 39
Musaffe Tuna, A. Chávez-Reyes, A. Tari (2005)
HER2/neu increases the expression of Wilms' Tumor 1 (WT1) protein to stimulate S-phase proliferation and inhibit apoptosis in breast cancer cellsOncogene, 24
D. Haber, R. Sohn, A. Buckler, J. Pelletier, K. Call, D. Housman (1991)
Alternative splicing and genomic structure of the Wilms tumor gene WT1.Proceedings of the National Academy of Sciences of the United States of America, 88
A. Tsao, J. Roth, R. Herbst (2010)
Surgery: Future directions in multimodality therapy for NSCLCNature Reviews Clinical Oncology, 7
V. Huff (2011)
Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon geneNature Reviews Cancer, 11
G. Dahle, T. Brøyn, K. Stavem (2003)
[Surgery for non-small cell lung cancer].Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 123 11
M-H Yang, S-Y Chang, S. Chiou, C.-J. Liu, C. Chi, P-M Chen, S. Teng, K-J Wu (2007)
Overexpression of NBS1 induces epithelial–mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancerOncogene, 26
D. Haber, A. Buckler, T. Glaser, K. Call, J. Pelletier, R. Sohn, E. Douglass, D. Housman (1990)
An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumorCell, 61
R. Siegel, D. Naishadham, A. Jemal (2012)
Cancer statistics, 2012CA: A Cancer Journal for Clinicians, 62
H. Ogawa, H. Tamaki, K. Ikegame, T. Soma, M. Kawakami, A. Tsuboi, E. Kim, N. Hosen, M. Murakami, T. Fujioka, T. Masuda, Y. Taniguchi, S. Nishida, Y. Oji, Y. Oka, H. Sugiyama (2003)
The usefulness of monitoring WT1 gene transcripts for the prediction and management of relapse following allogeneic stem cell transplantation in acute type leukemia.Blood, 101 5
Suzie Ariyaratana, D. Loeb (2007)
The role of the Wilms tumour gene (WT1) in normal and malignant haematopoiesisExpert Reviews in Molecular Medicine, 9
V. Scharnhorst, A. Eb, A. Jochemsen (2001)
WT1 proteins: functions in growth and differentiation.Gene, 273 2
M. Johnston (1997)
The limits of surgical resection alone for non-small cell lung cancer.Lung cancer, 17 Suppl 1
W. Bruening, P. Moffett, Shea Chia, G. Heinrich, J. Pelletier (1996)
Identification of nuclear localization signals within the zinc fingers of the WT1 tumor suppressor gene productFEBS Letters, 393
Wei Yan, Q. Cao, R. Arenas, Brooke Bentley, R. Shao (2010)
GATA3 Inhibits Breast Cancer Metastasis through the Reversal of Epithelial-Mesenchymal Transition*The Journal of Biological Chemistry, 285
E. Thompson, E. Williams (2008)
EMT and MET in carcinoma—clinical observations, regulatory pathways and new modelsClinical & Experimental Metastasis, 25
J. Meerbeeck (2008)
The controversial role of surgery in stage III NSCLC.The Lancet. Oncology, 9 7
Y. Oji, Y. Miyoshi, Eiji Kiyotoh, S. Koga, Y. Nakano, Akiko Ando, N. Hosen, A. Tsuboi, M. Kawakami, K. Ikegame, Y. Oka, H. Ogawa, S. Noguchi, H. Sugiyama (2004)
Absence of mutations in the Wilms' tumor gene WT1 in primary breast cancer.Japanese journal of clinical oncology, 34 2
C. Scheibenbogen, A. Letsch, E. Thiel, A. Schmittel, V. Mailaender, Steffi Baerwolf, D. Nagorsen, U. Keilholz (2002)
CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia.Blood, 100 6
K. Call, T. Glaser, C. Ito, A. Buckler, J. Pelletier, D. Haber, E. Rose, A. Kral, H. Yeger, W. Lewis, Carol Jones, D. Housman (1990)
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locusCell, 60
J. Tsai, J. Donaher, D. Murphy, S. Chau, Jing Yang (2012)
Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis.Cancer cell, 22 6
Ofelia Martínez-Estrada, L. Lettice, Abdelkader Essafi, J. Guadix, J. Slight, V. Velecela, Emma Hall, Judith Reichmann, Paul Devenney, P. Hohenstein, N. Hosen, R. Hill, R. Muñoz-Chápuli, N. Hastie (2009)
Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherinNature genetics, 42
J. Ward (2011)
NCCN Guidelines and the International Community.Journal of the National Comprehensive Cancer Network : JNCCN, 9 2
Raviprakash Sitaram, S. Degerman, B. Ljungberg, Emma Andersson, Y. Oji, H. Sugiyama, Göran Roos, Aihong Li (2010)
Wilms' tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathwaysBritish Journal of Cancer, 103
J. Furák, I. Troján, T. Szöke, L. Agócs, A. Csekeö, J. Kas, E. Svastics, J. Eller, L. Tiszlavicz (2005)
Lung cancer and its operable brain metastasis: survival rate and staging problems.The Annals of thoracic surgery, 79 1
Van Schil (2001)
Surgery for non-small cell lung cancerLung Cancer, 34
ORIGINAL ARTICLE WT1 Promotes Invasion of NSCLC via Suppression of CDH1 Chen Wu, PhD,* Weiyou Zhu, MD, PhD,* Jing Qian, MS,* Shaohua He, MS,* Changping Wu, MD, PhD,‡ Yijiang Chen, MD, PhD,† and Yongqian Shu, MD, PhD* The most common features of malignancy are inva- Introduction: The Wilms’ tumor gene (WT1) has been identified as sion and metastasis, which are characterized by the ability an oncogene in many malignant diseases, and aberrant WT1 expres- of cancer cells to invade into adjacent area, intravasate into sion has been linked to development, progression, and prognosis of blood or lymphatic vessels, and extravasate into a distant non–small-cell lung cancer (NSCLC). We sought to investigate the environment. Metastasis, which is primarily responsible for underlying mechanism of WT1 and metastasis in NSCLC. 10,11 the low 5-year survival rates (approximately 10%–15%), Methods: Real-time polymerase chain reaction was applied to detect is especially required for aggressive NSCLC, and once WT1 and CDH1 mRNA in 159 NSCLC samples and correspond- cancer cells lose contact with the neighboring cells, they ing adjacent tissues. Stable clones with overexpression and knock- become motile, invade the surrounding area, migrate, enter down of WT1 were generated with plasmid and shRNA via lentivirus the circulation, extravasate into the target organ, proliferate,
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Sep 1, 2013
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.