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WT1 CDH1

WT1 CDH1 ORIGINAL ARTICLE WT1 Promotes Invasion of NSCLC via Suppression of CDH1 Chen Wu, PhD,* Weiyou Zhu, MD, PhD,* Jing Qian, MS,* Shaohua He, MS,* Changping Wu, MD, PhD,‡ Yijiang Chen, MD, PhD,† and Yongqian Shu, MD, PhD* The most common features of malignancy are inva- Introduction: The Wilms’ tumor gene (WT1) has been identified as sion and metastasis, which are characterized by the ability an oncogene in many malignant diseases, and aberrant WT1 expres- of cancer cells to invade into adjacent area, intravasate into sion has been linked to development, progression, and prognosis of blood or lymphatic vessels, and extravasate into a distant non–small-cell lung cancer (NSCLC). We sought to investigate the environment. Metastasis, which is primarily responsible for underlying mechanism of WT1 and metastasis in NSCLC. 10,11 the low 5-year survival rates (approximately 10%–15%), Methods: Real-time polymerase chain reaction was applied to detect is especially required for aggressive NSCLC, and once WT1 and CDH1 mRNA in 159 NSCLC samples and correspond- cancer cells lose contact with the neighboring cells, they ing adjacent tissues. Stable clones with overexpression and knock- become motile, invade the surrounding area, migrate, enter down of WT1 were generated with plasmid and shRNA via lentivirus the circulation, extravasate into the target organ, proliferate, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

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References (44)

Copyright
Copyright © 2013 by the International Association for the Study of Lung Cancer
ISSN
1556-0864
DOI
10.1097/JTO.0b013e31829f6a5f
pmid
23945386
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE WT1 Promotes Invasion of NSCLC via Suppression of CDH1 Chen Wu, PhD,* Weiyou Zhu, MD, PhD,* Jing Qian, MS,* Shaohua He, MS,* Changping Wu, MD, PhD,‡ Yijiang Chen, MD, PhD,† and Yongqian Shu, MD, PhD* The most common features of malignancy are inva- Introduction: The Wilms’ tumor gene (WT1) has been identified as sion and metastasis, which are characterized by the ability an oncogene in many malignant diseases, and aberrant WT1 expres- of cancer cells to invade into adjacent area, intravasate into sion has been linked to development, progression, and prognosis of blood or lymphatic vessels, and extravasate into a distant non–small-cell lung cancer (NSCLC). We sought to investigate the environment. Metastasis, which is primarily responsible for underlying mechanism of WT1 and metastasis in NSCLC. 10,11 the low 5-year survival rates (approximately 10%–15%), Methods: Real-time polymerase chain reaction was applied to detect is especially required for aggressive NSCLC, and once WT1 and CDH1 mRNA in 159 NSCLC samples and correspond- cancer cells lose contact with the neighboring cells, they ing adjacent tissues. Stable clones with overexpression and knock- become motile, invade the surrounding area, migrate, enter down of WT1 were generated with plasmid and shRNA via lentivirus the circulation, extravasate into the target organ, proliferate,

Journal

Journal of Thoracic OncologyWolters Kluwer Health

Published: Sep 1, 2013

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