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What is needed to eliminate new pediatric HIV infections the contribution of model-based analyses

What is needed to eliminate new pediatric HIV infections the contribution of model-based analyses REVIEW URRENT What is needed to eliminate new pediatric HIV PINION infections: the contribution of model-based analyses a b Katie Doherty and Andrea Ciaranello Purpose of review Computer simulation models can identify key clinical, operational, and economic interventions that will be needed to achieve the elimination of new pediatric HIV infections. In this review, we summarize recent findings from model-based analyses of strategies for prevention of mother-to-child HIV transmission (MTCT). Recent findings In order to achieve elimination of MTCT (eMTCT), model-based studies suggest that scale-up of services will be needed in several domains: uptake of services and retention in care (the PMTCT ‘cascade’), interventions to prevent HIV infections in women and reduce unintended pregnancies (the ‘four-pronged approach’), efforts to support medication adherence through long periods of pregnancy and breastfeeding, and strategies to make breastfeeding safer and/or shorter. Models also project the economic resources that will be needed to achieve these goals in the most efficient ways to allocate limited resources for eMTCT. Results suggest that currently recommended PMTCT regimens (WHO Option A, Option B, and Option Bþ) will be cost-effective in most settings. Summary Model-based results can guide future implementation science, by highlighting areas in which additional data are http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

What is needed to eliminate new pediatric HIV infections the contribution of model-based analyses

Ciaranello, Andrea
Current Opinion in HIV and Aids , Volume 8 (5) – Sep 1, 2013
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Copyright
© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e328362db0d
pmid
23743788
Publisher site
See Article on Publisher Site

Abstract

REVIEW URRENT What is needed to eliminate new pediatric HIV PINION infections: the contribution of model-based analyses a b Katie Doherty and Andrea Ciaranello Purpose of review Computer simulation models can identify key clinical, operational, and economic interventions that will be needed to achieve the elimination of new pediatric HIV infections. In this review, we summarize recent findings from model-based analyses of strategies for prevention of mother-to-child HIV transmission (MTCT). Recent findings In order to achieve elimination of MTCT (eMTCT), model-based studies suggest that scale-up of services will be needed in several domains: uptake of services and retention in care (the PMTCT ‘cascade’), interventions to prevent HIV infections in women and reduce unintended pregnancies (the ‘four-pronged approach’), efforts to support medication adherence through long periods of pregnancy and breastfeeding, and strategies to make breastfeeding safer and/or shorter. Models also project the economic resources that will be needed to achieve these goals in the most efficient ways to allocate limited resources for eMTCT. Results suggest that currently recommended PMTCT regimens (WHO Option A, Option B, and Option Bþ) will be cost-effective in most settings. Summary Model-based results can guide future implementation science, by highlighting areas in which additional data are

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: Sep 1, 2013

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