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What is anaphylaxis?

What is anaphylaxis? What is anaphylaxis? David B.K. Golden Purpose of review Introduction In the century since the discovery of anaphylaxis, research Anaphylaxis is underrecognized, underreported, under- has yet to identify the mechanisms that cause a localized treated and poorly understood [1 – 3]. This is a very allergic response to become rapidly generalized, and surprising statement over 100 years after the first descrip- particularly why only some sensitized individuals develop tion of anaphylaxis, given that progress in our knowledge the clinical reaction on exposure. The possible components of immunology has permitted remarkable advances in and steps in the process (proven and hypothetical) are diagnosis and treatment of other allergic conditions. The reviewed with respect to their variation and regulation and epidemiology of anaphylaxis has been described in very their potential for therapeutic intervention. few published reports [4 – 11]. There are about 100 000 Recent findings episodes each year in the USA, of which two-thirds are Studies of insect sting allergy have revealed some of the new cases, and almost 1% are fatal. Some have estimated gaps in our understanding, the relatively poor predictive that 10 – 20% of the US population is at risk for anaphy- value of our diagnostic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Allergy and Clinical Immunology Wolters Kluwer Health

What is anaphylaxis?

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References (65)

ISSN
1528-4050
eISSN
1473-6322
DOI
10.1097/ACI.0b013e3281f8290c
pmid
17620825
Publisher site
See Article on Publisher Site

Abstract

What is anaphylaxis? David B.K. Golden Purpose of review Introduction In the century since the discovery of anaphylaxis, research Anaphylaxis is underrecognized, underreported, under- has yet to identify the mechanisms that cause a localized treated and poorly understood [1 – 3]. This is a very allergic response to become rapidly generalized, and surprising statement over 100 years after the first descrip- particularly why only some sensitized individuals develop tion of anaphylaxis, given that progress in our knowledge the clinical reaction on exposure. The possible components of immunology has permitted remarkable advances in and steps in the process (proven and hypothetical) are diagnosis and treatment of other allergic conditions. The reviewed with respect to their variation and regulation and epidemiology of anaphylaxis has been described in very their potential for therapeutic intervention. few published reports [4 – 11]. There are about 100 000 Recent findings episodes each year in the USA, of which two-thirds are Studies of insect sting allergy have revealed some of the new cases, and almost 1% are fatal. Some have estimated gaps in our understanding, the relatively poor predictive that 10 – 20% of the US population is at risk for anaphy- value of our diagnostic

Journal

Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health

Published: Aug 1, 2007

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