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Vascular Wall Growth Control

Vascular Wall Growth Control Review The Role of the Endothelium Stephen M. Schwartz, Corinne M. Gajdusek, and Sydney C. Selden, III t is now generally accepted that abnormal growth of smooth muscle cells plays a central General Considerations: and characteristic role in the development of Control of Growth by Cell-Cell Interaction atherosclerotic lesions. We need to know the Control of Growth by Nutrients and identity of the factors and mechanisms that stim- Growth Factors ulate this abnormal growth. "* In contrast, issues Movement and Replication surrounding control of endothelial growth are dif- Control of Growth at Wound Edges ferent and less obvious. There is no evidence Protein Synthesis in Regenerating Cells that excess growth of endothelium contributes to Endothelial Growth: the formation of lesions. There is evidence, how- Regeneration of Endothelium In Vivo vs ever, that endothelial injury leads to proliferation In Vitro and migration of smooth muscle cells into Life Span In Vivo and In Vitro lesions as a result of the release of platelet- Role of Growth Factors derived growth factor at sites where endothelial 1 2 continuity is disrupted. ' Moreover, loss of endo- Endothelial Injury: thelial integrity is also crucial to thrombosis and Denuding and Nondenuding important to the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis Wolters Kluwer Health

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Copyright
© 1981 by American Heart Association, Inc.
ISSN
0276-5047

Abstract

Review The Role of the Endothelium Stephen M. Schwartz, Corinne M. Gajdusek, and Sydney C. Selden, III t is now generally accepted that abnormal growth of smooth muscle cells plays a central General Considerations: and characteristic role in the development of Control of Growth by Cell-Cell Interaction atherosclerotic lesions. We need to know the Control of Growth by Nutrients and identity of the factors and mechanisms that stim- Growth Factors ulate this abnormal growth. "* In contrast, issues Movement and Replication surrounding control of endothelial growth are dif- Control of Growth at Wound Edges ferent and less obvious. There is no evidence Protein Synthesis in Regenerating Cells that excess growth of endothelium contributes to Endothelial Growth: the formation of lesions. There is evidence, how- Regeneration of Endothelium In Vivo vs ever, that endothelial injury leads to proliferation In Vitro and migration of smooth muscle cells into Life Span In Vivo and In Vitro lesions as a result of the release of platelet- Role of Growth Factors derived growth factor at sites where endothelial 1 2 continuity is disrupted. ' Moreover, loss of endo- Endothelial Injury: thelial integrity is also crucial to thrombosis and Denuding and Nondenuding important to the

Journal

ArteriosclerosisWolters Kluwer Health

Published: Mar 1, 1981

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