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Value of D2-40 in the Differential Diagnosis of Pleural Neoplasms With Emphasis on Its Positivity in Solitary Fibrous Tumor

Value of D2-40 in the Differential Diagnosis of Pleural Neoplasms With Emphasis on Its Positivity... Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Value of D2-40 in the Differential Diagnosis of Pleural Neoplasms With Emphasis on Its Positivity in Solitary Fibrous Tumor Yingchuan Hu, MD, PhD,* Qi Yang, AAS,* Loralee A. McMahon, BA, HTL,* Hanlin L. Wang, MD, PhD,w and Haodong Xu, MD, PhD* ccurate diagnosis of malignant mesothelioma (MM) Abstract: D2-40 is a new monoclonal antibody recognizing A is crucial for clinical management and outcome. podoplanin and it is selective for lymphatic endothelium. Identification of the promising biomarker to assist with Several studies have confirmed the reliability of D2-40 in the differential diagnosis between MM and other neoplasms diagnosis of pleural malignant mesothelioma, but the evaluation is continuously desirable. D2-40 is a new monoclonal of this antibody in other pleural neoplasms is limited. The aim of antibody recognizing podoplanin, which has been shown this study was to determine the diagnostic value of D2-40 in to be highly specific for lymphatic endothelium. More segregation of malignant mesothelioma from other pleural or recently, this marker has emerged as a novel diagnostic lung neoplasms. Sixty-seven cases, including 36 pleural malig- marker for MM. Several studies have confirmed the 2–7 nant mesotheliomas, 15 solitary fibrous tumors, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Value of D2-40 in the Differential Diagnosis of Pleural Neoplasms With Emphasis on Its Positivity in Solitary Fibrous Tumor

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Publisher
Wolters Kluwer Health
ISSN
1541-2016
DOI
10.1097/PAI.0b013e3181da8387
Publisher site
See Article on Publisher Site

Abstract

Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Value of D2-40 in the Differential Diagnosis of Pleural Neoplasms With Emphasis on Its Positivity in Solitary Fibrous Tumor Yingchuan Hu, MD, PhD,* Qi Yang, AAS,* Loralee A. McMahon, BA, HTL,* Hanlin L. Wang, MD, PhD,w and Haodong Xu, MD, PhD* ccurate diagnosis of malignant mesothelioma (MM) Abstract: D2-40 is a new monoclonal antibody recognizing A is crucial for clinical management and outcome. podoplanin and it is selective for lymphatic endothelium. Identification of the promising biomarker to assist with Several studies have confirmed the reliability of D2-40 in the differential diagnosis between MM and other neoplasms diagnosis of pleural malignant mesothelioma, but the evaluation is continuously desirable. D2-40 is a new monoclonal of this antibody in other pleural neoplasms is limited. The aim of antibody recognizing podoplanin, which has been shown this study was to determine the diagnostic value of D2-40 in to be highly specific for lymphatic endothelium. More segregation of malignant mesothelioma from other pleural or recently, this marker has emerged as a novel diagnostic lung neoplasms. Sixty-seven cases, including 36 pleural malig- marker for MM. Several studies have confirmed the 2–7 nant mesotheliomas, 15 solitary fibrous tumors,

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Oct 1, 2010

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