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Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Utility of Antiphosphorylated H2AX Antibody (g-H2AX) in Diagnosing Metastatic Renal Cell Carcinoma Matthew J. Wasco, MD and Robert T. Pu, MD, PhD n certain cases, diagnosing metastatic renal cell carci- Abstract: The differential diagnosis of metastatic renal cell Inoma (RCC) can be a challenge. Although many RCCs carcinoma (RCC) includes, although is not limited to, hepato- have a classic morphology, higher grade tumors and cellular carcinoma (HCC) and adrenocortical carcinoma (ACC) metastases often have features that make the tumor due to overlapping morphology. Immunohistochemical mar- difficult to distinguish morphologically from other kers, including RCC marker (RCC-Ma) have been employed possible diagnoses. In particular, adrenocortical carci- with varying success in the differential diagnosis of RCC. Our noma (ACC) and hepatocellular carcinoma (HCC) are preliminary tissue microarray study demonstrated that g-H2AX, often in the differential diagnosis of a metastatic tumor an antibody that specifically reacts with phosphorylated histone when the primary tumor is not known or confirmed, or H2AX, stained many primary RCC strongly and did not stain when the tumor is located within the liver or adrenal HCC or ACC, prompting us to evaluate its utility in these gland. Both ACC
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Jul 1, 2008
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