Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Use of (alternative) coreceptors for HIV entry

Use of (alternative) coreceptors for HIV entry REVIEW URRENT PINION Georgios Pollakis and William A. Paxton Purpose of review Although CCR5 and CXCR4 are the predominant coreceptors associated with HIV-1 entry, many more coreceptors can support either infection or viral capture and have been associated with transmission and disease progression. Here, we describe the most recent findings pertinent to which receptors are involved with HIV-1 infection and the proposed consequences. Recent findings CCR5 or CXCR4 using HIV-1 can differentially utilize their respective coreceptors and influence which cell types are infected. Many alternate coreceptors have been described which expands the pool of cells within which HIV-1 can replicate or reside. A large number of C-type lectins have been described which capture HIV-1 and present the virus to CD4 T cells which can also be considered as receptors involved with transmission or disease course. The molecular mechanism through which gp120 binds host lectins, such as altered N-linked glycosylation profiling, provides further mechanisms influencing HIV-1 capture and transfer. Genetic polymorphisms within the alternative coreceptors have now been shown to associate with disease, implying they can play a significant role in HIV-1 disease. Summary We have summarized the recent findings concerning the multitude of receptors and coreceptors which can interact http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Use of (alternative) coreceptors for HIV entry

Current Opinion in HIV and Aids , Volume 7 (5) – Sep 1, 2012

Loading next page...
 
/lp/wolters-kluwer-health/use-of-alternative-coreceptors-for-hiv-entry-SAnvkqIfyJ

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Copyright
Copyright © Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited.
ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e328356e9f3
pmid
22842622
Publisher site
See Article on Publisher Site

Abstract

REVIEW URRENT PINION Georgios Pollakis and William A. Paxton Purpose of review Although CCR5 and CXCR4 are the predominant coreceptors associated with HIV-1 entry, many more coreceptors can support either infection or viral capture and have been associated with transmission and disease progression. Here, we describe the most recent findings pertinent to which receptors are involved with HIV-1 infection and the proposed consequences. Recent findings CCR5 or CXCR4 using HIV-1 can differentially utilize their respective coreceptors and influence which cell types are infected. Many alternate coreceptors have been described which expands the pool of cells within which HIV-1 can replicate or reside. A large number of C-type lectins have been described which capture HIV-1 and present the virus to CD4 T cells which can also be considered as receptors involved with transmission or disease course. The molecular mechanism through which gp120 binds host lectins, such as altered N-linked glycosylation profiling, provides further mechanisms influencing HIV-1 capture and transfer. Genetic polymorphisms within the alternative coreceptors have now been shown to associate with disease, implying they can play a significant role in HIV-1 disease. Summary We have summarized the recent findings concerning the multitude of receptors and coreceptors which can interact

Journal

Current Opinion in HIV and AidsWolters Kluwer Health

Published: Sep 1, 2012

There are no references for this article.