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Unique features of memory T cells in HIV elite controllers: a systems biology perspective a a b,c Simone G. Fonseca , Francesco A. Procopio , Jean-Philippe Goulet , b,c b,c a,b,c Bader Yassine-Diab , Petronela Ancuta and Rafick-Pierre Se´kaly Vaccine and Gene Therapy Institute-Florida (VGTI- Purpose of review FL), Port Sainte-Lucie, Florida, USA, Centre de Elite controllers constitute a rare group of HIV-infected individuals who control HIV Recherche du Centre Hospitalier de l’Universite ´ de Montreal (CRCHUM), Saint-Luc Hospital and replication and maintain normal CD4 cell counts without antiretroviral therapy (ART). Departement of Microbiology and Immunology, The mechanisms involved in the control of infection are poorly understood. This review Universite ´ de Montre ´ al, Montre ´ al, Que ´ bec, Canada will focus on the identification of signaling pathways upregulated or downregulated in Correspondance to Rafick-Pierre Se ´ kaly, VGTI-FL, different memory T-cell subsets in elite controllers by using systems biology 11350 SW Village Parkway, Port Sainte-Lucie, FL 34987, USA approaches. Features of memory T cells in simian immunodeficiency virus (SIV) natural Tel: +1 7723454780; fax: +1 772 345 3675; hosts will be also highlighted. Finally, we will discuss how these approaches will guide e-mail: sekaly@vgti-fl.org the development
Current Opinion in HIV and Aids – Wolters Kluwer Health
Published: May 1, 2011
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