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Triple-negative, Basal Marker-expressing, and High-grade Breast Carcinomas are Characterized by High Lymphatic Vessel Density and the Expression of Podoplanin in Stromal Fibroblasts

Triple-negative, Basal Marker-expressing, and High-grade Breast Carcinomas are Characterized by... RESEARCH ARTICLE Triple-negative, Basal Marker-expressing, and High-grade Breast Carcinomas are Characterized by High Lymphatic Vessel Density and the Expression of Podoplanin in Stromal Fibroblasts Joanna A. Niemiec, PhD,* Agnieszka Adamczyk, PhD,* Aleksandra Ambicka, MD,w Anna Mucha-Ma!ecka, MD, PhD,z Wojciech M. Wysocki, MD, PhD,y and Janusz Rys´, MD, PhDw Key Words: breast cancer, podoplanin, lymphatic vessel density, Abstract: Podoplanin, expressed in the lymphatic but not in the basal subtype, basal markers blood vessel endothelium, is widely used as a specific marker for (Appl Immunohistochem Mol Morphol 2014;22:10–16) lymphatic endothelial cells and lymphangiogenesis. The relation between lymphatic vessel density and breast cancer subtype or the expression of basal markers has not yet been investigated. We assessed lymphatic vessel density (LVD), blood vessel den- ymphatic vessels are one of the principal routes for sity, and the expression of podoplanin in stromal cancer-asso- Lbreast cancer dissemination. Podoplanin, vascular ciated fibroblasts, in 156 invasive ductal breast cancers (TZ1, endothelial growth factor receptor-3 (VEGFR-3), Prox-1 NZ1, M0). Afterwards, we assessed the relationship between and desmoplakin are lymphatic vessel markers, playing the above-mentioned parameters and (i) breast cancer subtype multiple roles in the physiological and pathological 2,3 (luminal vs. HER2 vs. triple negative), (ii) tumor grade http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Triple-negative, Basal Marker-expressing, and High-grade Breast Carcinomas are Characterized by High Lymphatic Vessel Density and the Expression of Podoplanin in Stromal Fibroblasts

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Copyright
Copyright © 2013 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e318286030d
pmid
23455186
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Triple-negative, Basal Marker-expressing, and High-grade Breast Carcinomas are Characterized by High Lymphatic Vessel Density and the Expression of Podoplanin in Stromal Fibroblasts Joanna A. Niemiec, PhD,* Agnieszka Adamczyk, PhD,* Aleksandra Ambicka, MD,w Anna Mucha-Ma!ecka, MD, PhD,z Wojciech M. Wysocki, MD, PhD,y and Janusz Rys´, MD, PhDw Key Words: breast cancer, podoplanin, lymphatic vessel density, Abstract: Podoplanin, expressed in the lymphatic but not in the basal subtype, basal markers blood vessel endothelium, is widely used as a specific marker for (Appl Immunohistochem Mol Morphol 2014;22:10–16) lymphatic endothelial cells and lymphangiogenesis. The relation between lymphatic vessel density and breast cancer subtype or the expression of basal markers has not yet been investigated. We assessed lymphatic vessel density (LVD), blood vessel den- ymphatic vessels are one of the principal routes for sity, and the expression of podoplanin in stromal cancer-asso- Lbreast cancer dissemination. Podoplanin, vascular ciated fibroblasts, in 156 invasive ductal breast cancers (TZ1, endothelial growth factor receptor-3 (VEGFR-3), Prox-1 NZ1, M0). Afterwards, we assessed the relationship between and desmoplakin are lymphatic vessel markers, playing the above-mentioned parameters and (i) breast cancer subtype multiple roles in the physiological and pathological 2,3 (luminal vs. HER2 vs. triple negative), (ii) tumor grade

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jan 1, 2014

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