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Trefoil Peptides, E-cadherin, and β-catenin Expression in Sporadic Fundic Gland Polyps Further Evidence Toward the Benign Nature of These Lesions

Trefoil Peptides, E-cadherin, and β-catenin Expression in Sporadic Fundic Gland Polyps... RESEARCH ARTICLE Trefoil Peptides, E-cadherin, and b-catenin Expression in Sporadic Fundic Gland Polyps Further Evidence Toward the Benign Nature of These Lesions Anna D’Odorico, MD,* Mauro Cassaro, MD,w Sabina Grillo, MD,* Roberta Lazzari, PhD,* Andrea Buda, MD,* Pietro Cardellini, PhD,z Carlo Sturniolo Giacomo, MD,* and Massimo Rugge, MDw undic gland polyps (FGP) constitute the most Abstract: Sporadic fundic gland polyps (FGP) are the most Fcommon gastric polyps (47%), arising in 2 distinct common type of gastric polyps and their pathogenesis is still clinicopathologic scenarios: sporadic and syndromic. unclear, although a b-catenin gene mutation has been described. Sporadic FGP are encountered in 0.9% to 1.9% of They are regarded as benign lesions but low-grade dysplasia has patients who undergo upper gastrointestinal (GI) endo- been observed, arising more debate on their potential progres- scopic evaluation, and are most frequent in middle-aged 1,2 sion to a malignant phenotype. We investigated in FGP the role women. of factors involved in cell integrity, proliferation, and inter- Macroscopically and histologically, FGP are typi- cellular adhesion: trefoil peptides (TFF1, TFF2), MIB1, cally small polyps (2 to 5 mm) located on the gastric 3,4 E-cadherin, and b-catenin. We selected randomly 24 patients body and fundus, and may http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Trefoil Peptides, E-cadherin, and β-catenin Expression in Sporadic Fundic Gland Polyps Further Evidence Toward the Benign Nature of These Lesions

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ISSN
1541-2016
DOI
10.1097/PAI.0b013e3181a03188
pmid
19444076
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Trefoil Peptides, E-cadherin, and b-catenin Expression in Sporadic Fundic Gland Polyps Further Evidence Toward the Benign Nature of These Lesions Anna D’Odorico, MD,* Mauro Cassaro, MD,w Sabina Grillo, MD,* Roberta Lazzari, PhD,* Andrea Buda, MD,* Pietro Cardellini, PhD,z Carlo Sturniolo Giacomo, MD,* and Massimo Rugge, MDw undic gland polyps (FGP) constitute the most Abstract: Sporadic fundic gland polyps (FGP) are the most Fcommon gastric polyps (47%), arising in 2 distinct common type of gastric polyps and their pathogenesis is still clinicopathologic scenarios: sporadic and syndromic. unclear, although a b-catenin gene mutation has been described. Sporadic FGP are encountered in 0.9% to 1.9% of They are regarded as benign lesions but low-grade dysplasia has patients who undergo upper gastrointestinal (GI) endo- been observed, arising more debate on their potential progres- scopic evaluation, and are most frequent in middle-aged 1,2 sion to a malignant phenotype. We investigated in FGP the role women. of factors involved in cell integrity, proliferation, and inter- Macroscopically and histologically, FGP are typi- cellular adhesion: trefoil peptides (TFF1, TFF2), MIB1, cally small polyps (2 to 5 mm) located on the gastric 3,4 E-cadherin, and b-catenin. We selected randomly 24 patients body and fundus, and may

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Oct 1, 2009

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