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Treatment optimization an outline for future success

Treatment optimization an outline for future success REVIEW URRENT Treatment optimization: an outline for PINION future success a b c Charles Flexner , Ben Plumley , and David H. Brown Ripin Purpose of review In this issue of Current Opinion, the Guest Editors and their colleagues provide a comprehensive overview of current activities aimed at optimizing global HIV treatment. In this introduction, we outline current goals and approaches that will be described in more detail elsewhere in this issue. Recent findings Two recent conferences, the first and second Conference on Antiretroviral Drug Optimization (CADO), brought together experts from academia, governments, foundations, the pharmaceutical industry, and community activists to develop a global HIV-treatment research agenda for the coming decade focused on better therapies and how to make them accessible to a broader population of people living with HIV. Important recommendations included a focus on more efficient process chemistry for antiretroviral drugs, investigation of antiretroviral dose reduction as a possible optimization strategy, recognition of the increasing importance of concurrent infections and comorbidities especially tuberculosis and aging-related diseases, and identifying a highly effective and affordable nontoxic, once-daily fixed-dose combination regimen for first-line treatment. Summary HIV treatment optimization is a process intended to enhance the long-term efficacy, adherence, tolerability, safety, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Treatment optimization an outline for future success

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Copyright
© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0000000000000003
pmid
24100878
Publisher site
See Article on Publisher Site

Abstract

REVIEW URRENT Treatment optimization: an outline for PINION future success a b c Charles Flexner , Ben Plumley , and David H. Brown Ripin Purpose of review In this issue of Current Opinion, the Guest Editors and their colleagues provide a comprehensive overview of current activities aimed at optimizing global HIV treatment. In this introduction, we outline current goals and approaches that will be described in more detail elsewhere in this issue. Recent findings Two recent conferences, the first and second Conference on Antiretroviral Drug Optimization (CADO), brought together experts from academia, governments, foundations, the pharmaceutical industry, and community activists to develop a global HIV-treatment research agenda for the coming decade focused on better therapies and how to make them accessible to a broader population of people living with HIV. Important recommendations included a focus on more efficient process chemistry for antiretroviral drugs, investigation of antiretroviral dose reduction as a possible optimization strategy, recognition of the increasing importance of concurrent infections and comorbidities especially tuberculosis and aging-related diseases, and identifying a highly effective and affordable nontoxic, once-daily fixed-dose combination regimen for first-line treatment. Summary HIV treatment optimization is a process intended to enhance the long-term efficacy, adherence, tolerability, safety,

Journal

Current Opinion in HIV and AidsWolters Kluwer Health

Published: Nov 1, 2013

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