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Treatment of food anaphylaxis with traditional Chinese herbal remedies from mouse model to human clinical trials

Treatment of food anaphylaxis with traditional Chinese herbal remedies from mouse model to human... REVIEW URRENT Treatment of food anaphylaxis with traditional PINION Chinese herbal remedies: from mouse model to human clinical trials Julie Wang Purpose of review To describe the development of a novel treatment for food allergy, named the food allergy herbal formula-2 (FAHF-2), that is based on traditional Chinese medicine. Recent findings FAHF-2 has proven to be well tolerated and effective for the treatment of food allergies in murine models of peanut and multiple food allergies. These results are accompanied by evidence of favorable immune modulation, and the effects are persistent after the discontinuation of treatment. Early clinical trials demonstrate the safety and tolerability of this formula in individuals with food allergies. An ongoing Phase II clinical trial will evaluate the efficacy of FAHF-2 in protecting individuals from allergen-induced allergic reactions during oral food challenges. Summary FAHF-2 is an herbal formula that has a high safety profile and has shown to prevent anaphylaxis in murine models of food allergy. Similar findings in clinical trials could bring a novel treatment for food allergies. Keywords anaphylaxis, food allergy, herbs, traditional Chinese medicine, treatment INTRODUCTION children had used complementary or alternative medicine (CAM) in the last year, with the annual Food allergy continues http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Allergy and Clinical Immunology Wolters Kluwer Health

Treatment of food anaphylaxis with traditional Chinese herbal remedies from mouse model to human clinical trials

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Copyright
© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
ISSN
1528-4050
eISSN
1473-6322
DOI
10.1097/ACI.0b013e3283615bc4
pmid
23799334
Publisher site
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Abstract

REVIEW URRENT Treatment of food anaphylaxis with traditional PINION Chinese herbal remedies: from mouse model to human clinical trials Julie Wang Purpose of review To describe the development of a novel treatment for food allergy, named the food allergy herbal formula-2 (FAHF-2), that is based on traditional Chinese medicine. Recent findings FAHF-2 has proven to be well tolerated and effective for the treatment of food allergies in murine models of peanut and multiple food allergies. These results are accompanied by evidence of favorable immune modulation, and the effects are persistent after the discontinuation of treatment. Early clinical trials demonstrate the safety and tolerability of this formula in individuals with food allergies. An ongoing Phase II clinical trial will evaluate the efficacy of FAHF-2 in protecting individuals from allergen-induced allergic reactions during oral food challenges. Summary FAHF-2 is an herbal formula that has a high safety profile and has shown to prevent anaphylaxis in murine models of food allergy. Similar findings in clinical trials could bring a novel treatment for food allergies. Keywords anaphylaxis, food allergy, herbs, traditional Chinese medicine, treatment INTRODUCTION children had used complementary or alternative medicine (CAM) in the last year, with the annual Food allergy continues

Journal

Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health

Published: Aug 1, 2013

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