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Transient receptor potential channels and occupational exposure

Transient receptor potential channels and occupational exposure REVIEW URRENT Transient receptor potential channels and PINION occupational exposure a a,b a Pierangelo Geppetti , Riccardo Patacchini , and Romina Nassini Purpose of review The discovery that a number of transient receptor potential (TRP) channels are expressed in a subpopulation of primary sensory neurons innervating the upper and lower airways as well as in nonneuronal cells in the airways and lungs has initiated a quest for the understanding of their role in the physiology and pathophysiology of the respiratory tract. Recent findings Various members of the TRP vanilloid subfamily (TRPV1, TRPV4) and the TRP ankyrin 1 (TRPA1), because of their localization in peptidergic sensory neurons, promote airway neurogenic inflammation. In particular, TRPA1, which is gated by oxidative and nitrative stress byproducts, has been found to mediate inflammatory responses produced by an unprecedented series of toxic and irritant agents produced by air pollution, contained in cigarette smoke, and produced by accidental events at the workplace. The observation that reactive molecules endogenously produced in the airways/lungs of asthma, work-related asthma, and chronic obstructive pulmonary disease target TRPA1 underscores the primary role of the TRPA1 channel in these conditions. Summary Identification of TRP channels, and especially TRPA1, as major targets of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Allergy and Clinical Immunology Wolters Kluwer Health

Transient receptor potential channels and occupational exposure

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References (94)

Copyright
© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins
ISSN
1528-4050
eISSN
1473-6322
DOI
10.1097/ACI.0000000000000040
pmid
24451914
Publisher site
See Article on Publisher Site

Abstract

REVIEW URRENT Transient receptor potential channels and PINION occupational exposure a a,b a Pierangelo Geppetti , Riccardo Patacchini , and Romina Nassini Purpose of review The discovery that a number of transient receptor potential (TRP) channels are expressed in a subpopulation of primary sensory neurons innervating the upper and lower airways as well as in nonneuronal cells in the airways and lungs has initiated a quest for the understanding of their role in the physiology and pathophysiology of the respiratory tract. Recent findings Various members of the TRP vanilloid subfamily (TRPV1, TRPV4) and the TRP ankyrin 1 (TRPA1), because of their localization in peptidergic sensory neurons, promote airway neurogenic inflammation. In particular, TRPA1, which is gated by oxidative and nitrative stress byproducts, has been found to mediate inflammatory responses produced by an unprecedented series of toxic and irritant agents produced by air pollution, contained in cigarette smoke, and produced by accidental events at the workplace. The observation that reactive molecules endogenously produced in the airways/lungs of asthma, work-related asthma, and chronic obstructive pulmonary disease target TRPA1 underscores the primary role of the TRPA1 channel in these conditions. Summary Identification of TRP channels, and especially TRPA1, as major targets of

Journal

Current Opinion in Allergy and Clinical ImmunologyWolters Kluwer Health

Published: Apr 1, 2014

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