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F. Knieling, Deike Strobel, O. Rompel, M. Zapke, C. Menendez-Castro, M. Wölfel, J. Schulz, Wolfgang Rascher, Jörg Jüngert (2016)
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Circulation: Cardiovascular Imaging RESEARCH LETTER Transfontanellar Contrast–Enhanced Ultrasound for Monitoring Brain Perfusion During Neonatal Heart Surgery hile current mortality rates for neonatal heart surgery are low, there is Ferdinand Knieling, MD significant concern about the effects of cardiopulmonary bypass (CPB) André Rüffer, MD Won the neonatal brain and later neurodevelopmental impairments. To Robert Cesnjevar, MD date, no good techniques are available to study the effects of neonatal heart sur- Adrian P. Regensburger, gery on brain perfusion. MD The aim of this study is to investigate the potential of transfontanellar contrast– Ariawan Purbojo, MD enhanced ultrasound (T-CEUS) for quantitative assessment of cerebral blood flow Sven Dittrich, MD in different phases of neonatal cardiac surgery with and without CPB. Frank Münch, MS In a monocentric, explorative feasibility study n=5 patients with coarctation of Antje Neubert, PhD the aorta (CoA) and n=7 patients with transposition of great arteries (TGA) were Sebastian Meyer, PhD included (URL: http://www.clinicaltrials.gov. Unique identifier: NCT03215628) Deike Strobel, MD from September 18, 2017, to March 14, 2019. The study was approved by the Wolfgang Rascher, MD local ethics committee (20_17B). Informed consent for the study and the off-label Joachim Woelfle, MD use of the ultrasound contrast agent were obtained
Circulation: Cardiovascular Imaging – Wolters Kluwer Health
Published: Mar 1, 2020
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