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Towards an HIV cure based on targeted killing of infected cells different approaches against acute versus chronic infection

Towards an HIV cure based on targeted killing of infected cells different approaches against... REVIEW URRENT Towards an HIV cure based on targeted killing PINION of infected cells: different approaches against acute versus chronic infection Barna Dey and Edward A. Berger Purpose of review Current regimens of combination antiretroviral therapy (cART) offer effective control of HIV infection, with maintenance of immune health and near-normal life expectancy. What will it take to progress beyond the status quo, whereby infectious virus can be eradicated (a ‘sterilizing cure’) or fully controlled without the need for ongoing cART (a ‘functional cure’)? Recent findings On the basis of therapeutic advances in the cancer field, we propose that targeted cytotoxic therapy to kill HIV-infected cells represents a logical complement to cART for achieving an HIV cure. This concept is based on the fact that cART effectively blocks replication of the virus, but does not eliminate cells that are already infected; targeted cytotoxic therapy would contribute precisely this missing component. We suggest that different modalities are suited for curing primary acute versus established chronic infection. For acute infection, relatively short-acting potent agents such as recombinant immunotoxins might prove sufficient for HIV eradication, whereas for chronic infection, a long-lasting (lifelong?) modality is required to maintain full virus control, as might be http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Towards an HIV cure based on targeted killing of infected cells different approaches against acute versus chronic infection

Current Opinion in HIV and Aids , Volume 10 (3) – May 1, 2015

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Copyright
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0000000000000151
pmid
25710815
Publisher site
See Article on Publisher Site

Abstract

REVIEW URRENT Towards an HIV cure based on targeted killing PINION of infected cells: different approaches against acute versus chronic infection Barna Dey and Edward A. Berger Purpose of review Current regimens of combination antiretroviral therapy (cART) offer effective control of HIV infection, with maintenance of immune health and near-normal life expectancy. What will it take to progress beyond the status quo, whereby infectious virus can be eradicated (a ‘sterilizing cure’) or fully controlled without the need for ongoing cART (a ‘functional cure’)? Recent findings On the basis of therapeutic advances in the cancer field, we propose that targeted cytotoxic therapy to kill HIV-infected cells represents a logical complement to cART for achieving an HIV cure. This concept is based on the fact that cART effectively blocks replication of the virus, but does not eliminate cells that are already infected; targeted cytotoxic therapy would contribute precisely this missing component. We suggest that different modalities are suited for curing primary acute versus established chronic infection. For acute infection, relatively short-acting potent agents such as recombinant immunotoxins might prove sufficient for HIV eradication, whereas for chronic infection, a long-lasting (lifelong?) modality is required to maintain full virus control, as might be

Journal

Current Opinion in HIV and AidsWolters Kluwer Health

Published: May 1, 2015

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