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Parameters of flbrlnolysls, Including euglobulln fibrlnolytlc activity, tissue-type plasminogen activator (t-PA) antigen, plasminogen activator Inhibitor (PA-lnhlbltor) activity, and plasmln-α2-antlplasmln complex (PAP) were studied In 62 patients (35 women and 27 men; ages 53 ± 16 years) with either Insulin-dependent (IDDM) or nonlnsulln-dependent (NIDDM) diabetes mellKus. Compared to a control group of similar age (n = 57), the diabetic patients had a significantly lower mean euglobulln fibrlnolytlc activity (1.2 ±0.7 vs. 1.7 ±1.1 ng/ml, p<0.01) but significantly higher mean t-PA antigen (15.7 ± 8.4 vs. 6.6 ± 2.9 ng/ml, p<0.001) and PA-lnhlbltor activity (2.6 ± 1.3 vs. 1.5 ± 0.7 lU/ml, p<0.001) levels. Significant unlvarlate correlations were observed between PA-lnhlbttor activity and age (r=0.32, p<0.05), dlastollc blood pressure (r= 0.42, p<0.01) and euglobulin fibrlnolytlc activity (r= − 0.40, p<0.01). In multlvariate analysis, only body mass Index (positively) and euglobulin fibrlnolytlc activity (negatively) remained significantly related to PA-lnhlbltor activity In the total diabetic population as well as In the NIDDM group. The only parameter In the IDDM group significantly related to PA-lnhlbltor activity was dlastollc blood pressure. These results suggest that PA-lnhibltor plays a role In the regulation of flbrlnolysls In diabetes patients and that factors like obesity and hypertension may be related to reduced flbrlnolysls via PA-lnhlbltor levels.
Arteriosclerosis – Wolters Kluwer Health
Published: Jan 1, 1988
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