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Tissue Factor Expression in Non-small Cell Lung Cancer: Relationship with Vascular Endothelial Growth Factor Expression, Microvascular Density, and K- ras

Tissue Factor Expression in Non-small Cell Lung Cancer: Relationship with Vascular... ORIGINAL ARTICLE Tissue Factor Expression in Non-small Cell Lung Cancer: Relationship with Vascular Endothelial Growth Factor Expression, Microvascular Density, and K-ras Mutation Sandra Regina, MD,*†‡ Je´roˆme Rollin, PhD,†‡ Claire Ble´chet, MD,†‡§ Sophie Iochmann, PhD,*†‡ Pascale Reverdiau, PhD,*†‡ and Yves Gruel, MD*†‡ Several normal cells such as fibroblasts in the adventitia of Introduction: Tissue factor (TF) is the physiological trigger of blood vessels constitutively express TF, but cytokines, blood coagulation, but it could also have an important role in cancer growth factors, and endotoxins can also promote TF gene by regulating VEGF expression and angiogenesis. expression in vascular endothelial cells and circulating mono- Methods: TF expression was studied by real-time PCR in lung cytes. TF has also been recognized as having a key role in tumors of 64 patients with non-small-cell lung cancer (NSCLC) and certain cancers, particularly by regulating vascular endothelial by immunohistochemical analysis. The gene expression of two 3,4 growth factor (VEGF) expression and tumor angiogenesis. It is VEGF isoforms, VEGF and VEGF , was also evaluated. Mi- 165 189 5 now well established that certain tumor cells such as breast, crovascular density (MVD) was studied by measuring Von Wille- glioma, and pancreatic cancer cells express TF at http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Tissue Factor Expression in Non-small Cell Lung Cancer: Relationship with Vascular Endothelial Growth Factor Expression, Microvascular Density, and K- ras

Journal of Thoracic Oncology , Volume 3 (7) – Jul 1, 2008

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References (54)

ISSN
1556-0864
DOI
10.1097/JTO.0b013e31817c1b21
pmid
18594312
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Tissue Factor Expression in Non-small Cell Lung Cancer: Relationship with Vascular Endothelial Growth Factor Expression, Microvascular Density, and K-ras Mutation Sandra Regina, MD,*†‡ Je´roˆme Rollin, PhD,†‡ Claire Ble´chet, MD,†‡§ Sophie Iochmann, PhD,*†‡ Pascale Reverdiau, PhD,*†‡ and Yves Gruel, MD*†‡ Several normal cells such as fibroblasts in the adventitia of Introduction: Tissue factor (TF) is the physiological trigger of blood vessels constitutively express TF, but cytokines, blood coagulation, but it could also have an important role in cancer growth factors, and endotoxins can also promote TF gene by regulating VEGF expression and angiogenesis. expression in vascular endothelial cells and circulating mono- Methods: TF expression was studied by real-time PCR in lung cytes. TF has also been recognized as having a key role in tumors of 64 patients with non-small-cell lung cancer (NSCLC) and certain cancers, particularly by regulating vascular endothelial by immunohistochemical analysis. The gene expression of two 3,4 growth factor (VEGF) expression and tumor angiogenesis. It is VEGF isoforms, VEGF and VEGF , was also evaluated. Mi- 165 189 5 now well established that certain tumor cells such as breast, crovascular density (MVD) was studied by measuring Von Wille- glioma, and pancreatic cancer cells express TF at

Journal

Journal of Thoracic OncologyWolters Kluwer Health

Published: Jul 1, 2008

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