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ORIGINAL ARTICLE Thymoma A Population-Based Study of the Management and Outcomes for the Province of British Columbia Caroline Mariano, MD,* Diana N. Ionescu, MD,† Winson Y. Cheung, MD,* Rola H. Ali, MD,† Janessa Laskin, MD,* Ken Evans, MD,§ Hannah Carolan, MD,‡ and Nevin Murray, MD* hymomas are rare tumors with an incidence of approxi- Introduction: Thymomas are rare neoplasms with variable clinical Tmately 0.15 cases per 100,000 person years. Unfortunately, behavior. Our primary study aim was to analyze treatment practices little is known about the etiology of these malignancies and and outcomes in a population-based cohort of thymoma patients. their clinical behavior can be quite variable. There has been We hypothesized that stage I and II thymomas would have high cure widespread debate about their optimal classification. In 1995, rates with resection and adjuvant radiation, whereas locally advanced the World Health Organization (WHO) proposed a new patho- cases would benefit from multimodality therapy. logic staging system that has since been widely accepted and Methods: All patients, diagnosed with thymoma or thymic carci- 3–5 has been proven to have prognostic value. noma in British Columbia between 1994 and 2009, were identified The management of these tumors also continues to using
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Jan 1, 2013
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