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Thymic Tumors Relevant Molecular Data in the Clinic

Thymic Tumors Relevant Molecular Data in the Clinic MALIGNANCIES OF THE THYMUS Thymic Tumors Relevant Molecular Data in the Clinic Nicolas Girard, MD carcinoma based on the morphology of epithelial cells (with Introduction: Thymic malignancies are rare intrathoracic tumors an increasing degree of atypia from type A to thymic carci- that may be aggressive and difficult to treat in advanced stage. Over noma), the relative proportion of the nontumoral lymphocytic the past years, significant efforts have been conducted to dissect the component (decreasing from types B1 to B3), and resem- molecular pathways involved in the carcinogenesis of these tumors. blance to normal thymic architecture. After surgery, thymo- Insights have been made following anecdotal clinical responses to mas have a tendency toward local and regional progression, targeted therapies, and large-scale genomic analyses have been whereas thymic carcinomas are highly aggressive tumors conducted. with frequent systemic involvement at time of diagnosis and Methods: Review of the literature, 1990 –2010. poor prognosis despite multimodal treatment including sur- Results: The Epidermal Growth Factor Receptor (EGFR) is fre- 3,4 gery, radiotherapy, and chemotherapy. Beyond histology, quently overexpressed in thymomas and thymic carcinomas, but tumor invasiveness as evaluated by the Masaoka et al. EGFR mutations are exceptional, and this does not support the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Thymic Tumors Relevant Molecular Data in the Clinic

Girard, Nicolas
Journal of Thoracic Oncology , Volume 5 – Oct 1, 2010
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ISSN
1556-0864
eISSN
1556-1380

Abstract

MALIGNANCIES OF THE THYMUS Thymic Tumors Relevant Molecular Data in the Clinic Nicolas Girard, MD carcinoma based on the morphology of epithelial cells (with Introduction: Thymic malignancies are rare intrathoracic tumors an increasing degree of atypia from type A to thymic carci- that may be aggressive and difficult to treat in advanced stage. Over noma), the relative proportion of the nontumoral lymphocytic the past years, significant efforts have been conducted to dissect the component (decreasing from types B1 to B3), and resem- molecular pathways involved in the carcinogenesis of these tumors. blance to normal thymic architecture. After surgery, thymo- Insights have been made following anecdotal clinical responses to mas have a tendency toward local and regional progression, targeted therapies, and large-scale genomic analyses have been whereas thymic carcinomas are highly aggressive tumors conducted. with frequent systemic involvement at time of diagnosis and Methods: Review of the literature, 1990 –2010. poor prognosis despite multimodal treatment including sur- Results: The Epidermal Growth Factor Receptor (EGFR) is fre- 3,4 gery, radiotherapy, and chemotherapy. Beyond histology, quently overexpressed in thymomas and thymic carcinomas, but tumor invasiveness as evaluated by the Masaoka et al. EGFR mutations are exceptional, and this does not support the

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Oct 1, 2010

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