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Three Molecular Subtypes of Gastric Adenocarcinoma Have Distinct Histochemical Features Reflecting Epstein-Barr Virus Infection Status and Neuroendocrine Differentiation

Three Molecular Subtypes of Gastric Adenocarcinoma Have Distinct Histochemical Features... RESEARCH ARTICLE Three Molecular Subtypes of Gastric Adenocarcinoma Have Distinct Histochemical Features Reflecting Epstein-Barr Virus Infection Status and Neuroendocrine Differentiation Olga Speck, MD, PhD,* Weihua Tang, MD, PhD,* Douglas R. Morgan, MD, MPH,w Pei Fen Kuan, PhD,z Michael O. Meyers, MD,y Ricardo L. Dominguez, MD,8 Enrique Martinez, MD,z and Margaret L. Gulley, MD* adenocarcinomas. Evidence of NE differentiation (molecular, Abstract: Current histopathologic classification schemes for immunohistochemical, or morphologic) was mutually exclusive gastric adenocarcinoma have limited clinical utility and are of EBV infection. EBV-infected tumors tended to have solid- difficult to apply due to tumor heterogeneity. Elucidation of type morphology with lymphoid stroma. This study reveals molecular subtypes of gastric cancer may contribute to our novel molecular subtypes of gastric cancer and their associated understanding of gastric cancer biology and to the development morphologies that demonstrate divergent NE features. of new molecular markers that may lead to improved diagnosis, Key Words: gastric cancer, EBV-associated gastric ad- therapy, or prognosis. We previously demonstrated that enocarcinoma, gastric cancer with lymphoid stroma, neuro- Epstein-Barr virus (EBV)-infected gastric cancers have a distinct endocrine differentiation, neuroendocrine carcinoma human gene expression profile compared with uninfected can- cers. We now examine the histopathologic features characteriz- (Appl Immunohistochem http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Three Molecular Subtypes of Gastric Adenocarcinoma Have Distinct Histochemical Features Reflecting Epstein-Barr Virus Infection Status and Neuroendocrine Differentiation

Applied Immunohistochemistry & Molecular Morphology , Volume Publish Ahead of Print – Dec 1, 2014

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Copyright
Copyright © 2014 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0000000000000122
pmid
25517873
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Three Molecular Subtypes of Gastric Adenocarcinoma Have Distinct Histochemical Features Reflecting Epstein-Barr Virus Infection Status and Neuroendocrine Differentiation Olga Speck, MD, PhD,* Weihua Tang, MD, PhD,* Douglas R. Morgan, MD, MPH,w Pei Fen Kuan, PhD,z Michael O. Meyers, MD,y Ricardo L. Dominguez, MD,8 Enrique Martinez, MD,z and Margaret L. Gulley, MD* adenocarcinomas. Evidence of NE differentiation (molecular, Abstract: Current histopathologic classification schemes for immunohistochemical, or morphologic) was mutually exclusive gastric adenocarcinoma have limited clinical utility and are of EBV infection. EBV-infected tumors tended to have solid- difficult to apply due to tumor heterogeneity. Elucidation of type morphology with lymphoid stroma. This study reveals molecular subtypes of gastric cancer may contribute to our novel molecular subtypes of gastric cancer and their associated understanding of gastric cancer biology and to the development morphologies that demonstrate divergent NE features. of new molecular markers that may lead to improved diagnosis, Key Words: gastric cancer, EBV-associated gastric ad- therapy, or prognosis. We previously demonstrated that enocarcinoma, gastric cancer with lymphoid stroma, neuro- Epstein-Barr virus (EBV)-infected gastric cancers have a distinct endocrine differentiation, neuroendocrine carcinoma human gene expression profile compared with uninfected can- cers. We now examine the histopathologic features characteriz- (Appl Immunohistochem

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Dec 1, 2014

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