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The WHO Classification of Lymphomas: Cost-effective Immunohistochemistry Using a Deductive Reasoning “Decision Tree” Approach Part II: The Decision Tree Approach: Diffuse Patterns of Proliferation in Lymph Nodes

The WHO Classification of Lymphomas: Cost-effective Immunohistochemistry Using a Deductive... REVIEW ARTICLE The WHO Classification of Lymphomas: Cost-effective Immunohistochemistry Using a Deductive Reasoning ‘‘Decision Tree’’ Approach Part II: The Decision Tree Approach: Diffuse Patterns of Proliferation in Lymph Nodes Clive R. Taylor, MA, MD, DPhil art I of this review examined the role of immunohis- Abstract: The 2008 World Health Organization Classification of Ptochemistry (IHC) in practical application of the Tumors of the Haematopoietic and Lymphoid Tissues defines World Health Organization (WHO) Classification of current standards of practice for the diagnosis and classification Tumors of the Haematopoietic and Lymphoid Tissues. of malignant lymphomas and related entities. More than 50 The chosen context is a lymph node biopsy in which the different types of lymphomas are described. Faced with such a pathologist must make 1 or more decisions in sequence. broad range of different lymphomas, some encountered only Is the lesion rarely, and a rapidly growing armamentarium of 80 or more 1. Reactive hyperplasia or neoplasia (‘‘benign’’ vs. ‘‘malig- pertinent immunohistochemical (IHC) ‘‘stains,’’ the challenge to nant’’)? the pathologist is to use IHC in an efficient manner to arrive 2. If malignant, lymphoma or metastasis? at an assured and timely diagnosis. This review uses deductive 3. If lymphoma, ‘‘non-Hodgkin’’ or http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

The WHO Classification of Lymphomas: Cost-effective Immunohistochemistry Using a Deductive Reasoning “Decision Tree” Approach Part II: The Decision Tree Approach: Diffuse Patterns of Proliferation in Lymph Nodes

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ISSN
1541-2016
DOI
10.1097/PAI.0b013e3181bc84f4
pmid
19786864
Publisher site
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Abstract

REVIEW ARTICLE The WHO Classification of Lymphomas: Cost-effective Immunohistochemistry Using a Deductive Reasoning ‘‘Decision Tree’’ Approach Part II: The Decision Tree Approach: Diffuse Patterns of Proliferation in Lymph Nodes Clive R. Taylor, MA, MD, DPhil art I of this review examined the role of immunohis- Abstract: The 2008 World Health Organization Classification of Ptochemistry (IHC) in practical application of the Tumors of the Haematopoietic and Lymphoid Tissues defines World Health Organization (WHO) Classification of current standards of practice for the diagnosis and classification Tumors of the Haematopoietic and Lymphoid Tissues. of malignant lymphomas and related entities. More than 50 The chosen context is a lymph node biopsy in which the different types of lymphomas are described. Faced with such a pathologist must make 1 or more decisions in sequence. broad range of different lymphomas, some encountered only Is the lesion rarely, and a rapidly growing armamentarium of 80 or more 1. Reactive hyperplasia or neoplasia (‘‘benign’’ vs. ‘‘malig- pertinent immunohistochemical (IHC) ‘‘stains,’’ the challenge to nant’’)? the pathologist is to use IHC in an efficient manner to arrive 2. If malignant, lymphoma or metastasis? at an assured and timely diagnosis. This review uses deductive 3. If lymphoma, ‘‘non-Hodgkin’’ or

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Dec 1, 2009

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