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The Utility of Phosphohistone H3 in Breast Cancer Grading

The Utility of Phosphohistone H3 in Breast Cancer Grading RESEARCH ARTICLE Xiaoyan Cui, MD, PhD, Shuko Harada, MD, Dejun Shen, MD, PhD, Gene P. Siegal, MD, PhD, and Shi Wei, MD, PhD formation, nuclear pleomorphism, and the mitotic count. Abstract: The commonly used Nottingham Grading System in The importance of mitotic activity has been further il- breast cancer takes into consideration the presence of tubular lustrated by a large-scaled previous study, in which the formation, nuclear pleomorphism, and the mitotic index (MI), mitotic index (MI) was the only significant prognostic among which the latter has been shown to be the most powerful factor when separately analyzing the prognostic value of prognostic factor. In practice, histologic grading is highly sub- each of the 3 components. First advocated in 1991, the jective, with only moderate interobserver reproducibility. prognostic significance of the Nottingham Grading Sys- Phosphorylation of histone H3 has been demonstrated to be a tem has been validated by multiple independent studies 2–8 specific event in the mitotic phase, and is negligible during in- over the past 2 decades. Thus, the routine reporting of terphase. In this study, we evaluated the efficacy of Phospho- tumor grade has been recommended by the World Health histone H3 (PHH3) in the breast cancer http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

The Utility of Phosphohistone H3 in Breast Cancer Grading

Applied Immunohistochemistry & Molecular Morphology , Volume Publish Ahead of Print – Jan 1, 2015

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Copyright
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1541-2016
DOI
10.1097/PAI.0000000000000137
pmid
25611243
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Xiaoyan Cui, MD, PhD, Shuko Harada, MD, Dejun Shen, MD, PhD, Gene P. Siegal, MD, PhD, and Shi Wei, MD, PhD formation, nuclear pleomorphism, and the mitotic count. Abstract: The commonly used Nottingham Grading System in The importance of mitotic activity has been further il- breast cancer takes into consideration the presence of tubular lustrated by a large-scaled previous study, in which the formation, nuclear pleomorphism, and the mitotic index (MI), mitotic index (MI) was the only significant prognostic among which the latter has been shown to be the most powerful factor when separately analyzing the prognostic value of prognostic factor. In practice, histologic grading is highly sub- each of the 3 components. First advocated in 1991, the jective, with only moderate interobserver reproducibility. prognostic significance of the Nottingham Grading Sys- Phosphorylation of histone H3 has been demonstrated to be a tem has been validated by multiple independent studies 2–8 specific event in the mitotic phase, and is negligible during in- over the past 2 decades. Thus, the routine reporting of terphase. In this study, we evaluated the efficacy of Phospho- tumor grade has been recommended by the World Health histone H3 (PHH3) in the breast cancer

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jan 1, 2015

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