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RESEARCH ARTICLE Xiaoyan Cui, MD, PhD, Shuko Harada, MD, Dejun Shen, MD, PhD, Gene P. Siegal, MD, PhD, and Shi Wei, MD, PhD formation, nuclear pleomorphism, and the mitotic count. Abstract: The commonly used Nottingham Grading System in The importance of mitotic activity has been further il- breast cancer takes into consideration the presence of tubular lustrated by a large-scaled previous study, in which the formation, nuclear pleomorphism, and the mitotic index (MI), mitotic index (MI) was the only significant prognostic among which the latter has been shown to be the most powerful factor when separately analyzing the prognostic value of prognostic factor. In practice, histologic grading is highly sub- each of the 3 components. First advocated in 1991, the jective, with only moderate interobserver reproducibility. prognostic significance of the Nottingham Grading Sys- Phosphorylation of histone H3 has been demonstrated to be a tem has been validated by multiple independent studies 2–8 specific event in the mitotic phase, and is negligible during in- over the past 2 decades. Thus, the routine reporting of terphase. In this study, we evaluated the efficacy of Phospho- tumor grade has been recommended by the World Health histone H3 (PHH3) in the breast cancer
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Jan 1, 2015
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