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The Utility of GATA3 in the Diagnosis of Urothelial Carcinomas With Variant Morphologic Patterns

The Utility of GATA3 in the Diagnosis of Urothelial Carcinomas With Variant Morphologic Patterns RESEARCH ARTICLE The Utility of GATA3 in the Diagnosis of Urothelial Carcinomas With Variant Morphologic Patterns Lindsey Verduin, MD, Mark J. Mentrikoski, MD, Christopher T. Heitz, MD, and Mark R. Wick, MD TA3 in adult urothelium and mammary ductal Abstract: The transcription factor GATA3 is a recently described epithelium. Several studies since then have expanded on biomarker that is highly expressed in bladder and breast carci- those findings, showing the utility of GATA3 im- nomas. Although it has shown sensitivity as a marker of primary munostaining in the identification of urothelial, breast, bladder carcinomas with purely urothelial differentiation, the 3,4 and cutaneous adnexal neoplasms, among others. Al- ability of GATA3 to label primary bladder carcinomas with though it is a sensitive marker for primary bladder car- variant morphologic patterns has been incompletely assessed to cinomas showing purely urothelial differentiation, the date. The current study was designed to determine whether GA- presence of GATA3 in bladder carcinomas with variant TA3 staining is retained in “unconventional” bladder carcinomas. morphologic patterns has been incompletely studied. This Eighty-eight cases of primary bladder cancers were retrieved from study was designed to assess whether GATA3 immunor- the authors’ institutional archive, and they included the following http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

The Utility of GATA3 in the Diagnosis of Urothelial Carcinomas With Variant Morphologic Patterns

Applied Immunohistochemistry & Molecular Morphology , Volume Publish Ahead of Print – Aug 1, 2015

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Copyright
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1541-2016
DOI
10.1097/PAI.0000000000000221
pmid
26317312
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE The Utility of GATA3 in the Diagnosis of Urothelial Carcinomas With Variant Morphologic Patterns Lindsey Verduin, MD, Mark J. Mentrikoski, MD, Christopher T. Heitz, MD, and Mark R. Wick, MD TA3 in adult urothelium and mammary ductal Abstract: The transcription factor GATA3 is a recently described epithelium. Several studies since then have expanded on biomarker that is highly expressed in bladder and breast carci- those findings, showing the utility of GATA3 im- nomas. Although it has shown sensitivity as a marker of primary munostaining in the identification of urothelial, breast, bladder carcinomas with purely urothelial differentiation, the 3,4 and cutaneous adnexal neoplasms, among others. Al- ability of GATA3 to label primary bladder carcinomas with though it is a sensitive marker for primary bladder car- variant morphologic patterns has been incompletely assessed to cinomas showing purely urothelial differentiation, the date. The current study was designed to determine whether GA- presence of GATA3 in bladder carcinomas with variant TA3 staining is retained in “unconventional” bladder carcinomas. morphologic patterns has been incompletely studied. This Eighty-eight cases of primary bladder cancers were retrieved from study was designed to assess whether GATA3 immunor- the authors’ institutional archive, and they included the following

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Aug 1, 2015

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