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The Squamous Cells of Adenosquamous Carcinoma (ASCC) of the Prostate Might Represent a Terminally Differentiated Quiescent Component: Immunohistochemical Evidence From a Case of ASCC With Pleomorphic Giant Tumor Cells

The Squamous Cells of Adenosquamous Carcinoma (ASCC) of the Prostate Might Represent a Terminally... Appl Immunohistochem Mol Morphol Volume 25, Number 8, September 2016 Letters to the Editor most abundant one was composed of investigation in the field of melanocytic The Squamous Cells of blue tumors. To date, additional studies malignant cribriform glands that con- and guidelines are needed to evaluate tained cells with moderate cytologic Adenosquamous the diagnostic value of different im- atypia, and comprised 70% of the le- Carcinoma (ASCC) of munohistochemical and molecular sional volume. The second most fre- methods in this field. Beyond p16 and quent pattern showed solid islands of the Prostate Might cyclinD1 immunohistochemistry, Ki-67 cells with central tumor-type necrosis immunohistochemistry (Figs. 1G, H) or akin to the comedo-necrosis of breast Represent a Terminally searching for chromosomal imbalances carcinomas, and severe cytologic aty- Differentiated Quiescent and/or the loss of BAP1 could also help pia (Fig. 1A). Most of the tumor is- in differentiating benign blue nevi and lands that lacked comedo-necrosis, Component: 4,5,9 malignant melanomas. showed a central component of ma- Immunohistochemical lignant squamous cells with abrupt Arnaud Uguen, MD, PhD*wz keratinization and dyskeratosis instead Evidence From a Case of Briac Guibourg, BMw (Fig. 1B). Overall, the squamous ele- Marie Uguen, MD, MScw ments accounted for approximately http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

The Squamous Cells of Adenosquamous Carcinoma (ASCC) of the Prostate Might Represent a Terminally Differentiated Quiescent Component: Immunohistochemical Evidence From a Case of ASCC With Pleomorphic Giant Tumor Cells

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Publisher
Wolters Kluwer Health
Copyright
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1062-3345
eISSN
1533-4058
DOI
10.1097/PAI.0000000000000443
pmid
27753662
Publisher site
See Article on Publisher Site

Abstract

Appl Immunohistochem Mol Morphol Volume 25, Number 8, September 2016 Letters to the Editor most abundant one was composed of investigation in the field of melanocytic The Squamous Cells of blue tumors. To date, additional studies malignant cribriform glands that con- and guidelines are needed to evaluate tained cells with moderate cytologic Adenosquamous the diagnostic value of different im- atypia, and comprised 70% of the le- Carcinoma (ASCC) of munohistochemical and molecular sional volume. The second most fre- methods in this field. Beyond p16 and quent pattern showed solid islands of the Prostate Might cyclinD1 immunohistochemistry, Ki-67 cells with central tumor-type necrosis immunohistochemistry (Figs. 1G, H) or akin to the comedo-necrosis of breast Represent a Terminally searching for chromosomal imbalances carcinomas, and severe cytologic aty- Differentiated Quiescent and/or the loss of BAP1 could also help pia (Fig. 1A). Most of the tumor is- in differentiating benign blue nevi and lands that lacked comedo-necrosis, Component: 4,5,9 malignant melanomas. showed a central component of ma- Immunohistochemical lignant squamous cells with abrupt Arnaud Uguen, MD, PhD*wz keratinization and dyskeratosis instead Evidence From a Case of Briac Guibourg, BMw (Fig. 1B). Overall, the squamous ele- Marie Uguen, MD, MScw ments accounted for approximately

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Sep 1, 2017

References

  • A comprehensive review of incidence and survival in patients with rare histological variants of prostate cancer in the United States from 1973 to 2008
  • Prostate carcinoma with squamous differentiation: an analysis of 33 cases
  • Suqamous neoplasms
  • Adenosquamous carcinoma of the prostate: case report with DNA analysis, immunohistochemistry, and literature review
  • Squamous cell carcinoma of the prostate