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The Spectrum of Morphomolecular Abnormalities of the E-Cadherin/Catenin Complex in Pleomorphic Lobular Carcinoma of the Breast

The Spectrum of Morphomolecular Abnormalities of the E-Cadherin/Catenin Complex in... RESEARCH ARTICLE The Spectrum of Morphomolecular Abnormalities of the E-Cadherin/Catenin Complex in Pleomorphic Lobular Carcinoma of the Breast David J. Dabbs, MD, Malathy Kaplai, MD, Mamatha Chivukula, MD, Anisa Kanbour, MD, Amal Kanbour-Shakir, MD, PhD, and Gloria J. Carter, MD high nuclear grade and dyscohesive infiltrating and in situ Abstract: Pleomorphic lobular carcinoma of the breast is a high patterns. nuclear grade variant of lobular carcinoma. E-cadherin, a E-cadherin, an invasion suppressor gene, codes for a tumor-invasion suppressor gene, codes for a transmembrane transmembrane protein that functions in intercellular protein that functions in intercellular adhesion. The E-cadherin adhesion. The E-cadherin protein internal domain binds protein internal domain binds with a, b, g, and p120 catenins to with a, b, g, and p120 catenins to anchor the E-cadherin anchor the E-cadherin complex to the actin cytoskeleton of the complex to the actin cytoskeleton of the cell. The E- cell. The E-cadherin gene is routinely mutated in lobular cadherin gene is routinely mutated in lobular neoplasia, neoplasia. This study examines the morphomolecular spectrum resulting in absence of the extracellular E-cadherin of the components of the E-cadherin-catenin complex in lobular domain and lack of membrane immunostaining for the 6–17 neoplasia. Fifteen cases http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

The Spectrum of Morphomolecular Abnormalities of the E-Cadherin/Catenin Complex in Pleomorphic Lobular Carcinoma of the Breast

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References (61)

ISSN
1541-2016
DOI
10.1097/01.pai.0000213128.78665.3c
pmid
17721269
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE The Spectrum of Morphomolecular Abnormalities of the E-Cadherin/Catenin Complex in Pleomorphic Lobular Carcinoma of the Breast David J. Dabbs, MD, Malathy Kaplai, MD, Mamatha Chivukula, MD, Anisa Kanbour, MD, Amal Kanbour-Shakir, MD, PhD, and Gloria J. Carter, MD high nuclear grade and dyscohesive infiltrating and in situ Abstract: Pleomorphic lobular carcinoma of the breast is a high patterns. nuclear grade variant of lobular carcinoma. E-cadherin, a E-cadherin, an invasion suppressor gene, codes for a tumor-invasion suppressor gene, codes for a transmembrane transmembrane protein that functions in intercellular protein that functions in intercellular adhesion. The E-cadherin adhesion. The E-cadherin protein internal domain binds protein internal domain binds with a, b, g, and p120 catenins to with a, b, g, and p120 catenins to anchor the E-cadherin anchor the E-cadherin complex to the actin cytoskeleton of the complex to the actin cytoskeleton of the cell. The E- cell. The E-cadherin gene is routinely mutated in lobular cadherin gene is routinely mutated in lobular neoplasia, neoplasia. This study examines the morphomolecular spectrum resulting in absence of the extracellular E-cadherin of the components of the E-cadherin-catenin complex in lobular domain and lack of membrane immunostaining for the 6–17 neoplasia. Fifteen cases

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Sep 1, 2007

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