Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Palacios, D. Sarrió, M. García-Macías, B. Bryant, M. Sobel, M. Merino (2003)
Frequent E-cadherin Gene Inactivation by Loss of Heterozygosity in Pleomorphic Lobular Carcinoma of the BreastModern Pathology, 16
W. Zschiesche, I. Schonborn, J. Behrens, K. Herrenknecht, F. Hartveit, P. Lilleng, W. Birchmeier (1997)
Expression of E-cadherin and catenins in invasive mammary carcinomas.Anticancer research, 17 1B
Teresa Mastracci, Suzanna Tjan, A. Bane, F. O'Malley, I. Andrulis (2005)
E-cadherin alterations in atypical lobular hyperplasia and lobular carcinoma in situ of the breastModern Pathology, 18
A. Watson, L. Barcroft (2001)
Regulation of blastocyst formation.Frontiers in bioscience : a journal and virtual library, 6
M. Thoreson, P. Anastasiadis, J. Daniel, R. Ireton, M. Wheelock, Keith Johnson, Diana Hummingbird, A. Reynolds (2000)
Selective Uncoupling of P120ctn from E-Cadherin Disrupts Strong AdhesionThe Journal of Cell Biology, 148
Nicole Noren, Betty Liu, K. Burridge, B. Kreft (2000)
P120 Catenin Regulates the Actin Cytoskeleton via Rho Family GtpasesThe Journal of Cell Biology, 150
R. Hashizume, H. Koizumi, A. Ihara, T. Ohta, T. Uchikoshi (1996)
Expression of beta-catenin in normal breast tissue and breast carcinoma: a comparative study with epithelial cadherin and alpha-catenin.Histopathology, 29 2
R. Yoshida, N. Kimura, Y. Harada, N. Ohuchi (2001)
The loss of E-cadherin, α- and β-catenin expression is associated with metastasis and poor prognosis in invasive breast cancerInternational Journal of Oncology, 18
James Staddon, C. Smales, Charlotte Schulze, Fred Esch, L. Lee (1995)
p120, a p120-related protein (p100), and the cadherin/catenin complexThe Journal of Cell Biology, 130
J. Wheeler, H. Enterline (1976)
Lobular carcinoma of the breast in situ and infiltrating.Pathology annual, 11
H. Maluf, P. Swanson, F. Koerner (2001)
Solid Low-Grade In Situ Carcinoma of the Breast: Role of Associated Lesions and E-Cadherin in Differential DiagnosisThe American Journal of Surgical Pathology, 25
G. Berx, K. Becker, H. Höfler, F. Roy (1998)
Mutations of the human E‐cadherin (CDH1) geneHuman Mutation, 12
Shiozaki (1995)
Correlation between the intercellular adhesion molecule (E-Cadherin) and its associated protein (Alpha catenin) expression and metastasis in human digestive cancersNippon Rinsho, 53
K. Toyooka, S. Toyooka, A. Virmani, U. Sathyanarayana, D. Euhus, M. Gilcrease, J. Minna, A. Gazdar (2001)
Loss of expression and aberrant methylation of the CDH13 (H-cadherin) gene in breast and lung carcinomas.Cancer research, 61 11
R. Hashizume, H. Koizumi, A. Ihara, T. Ohta, T. Uchikoshi (1996)
Expression of β‐catenin in normal breast tissue and breast carcinoma: a comparative study with epithelial cadherin and α‐cateninHistopathology, 29
N. Sneige, Jianzhou Wang, B. Baker, S. Krishnamurthy, L. Middleton (2002)
Clinical, Histopathologic, and Biologic Features of Pleomorphic Lobular (Ductal-Lobular) Carcinoma In Situ of the Breast: A Report of 24 CasesModern Pathology, 15
M. Hatzfeld (2005)
The p120 family of cell adhesion molecules.European journal of cell biology, 84 2-3
R. Moll, M. Mitze, U. Frixen, Walter Birchmeier (1993)
Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas.The American journal of pathology, 143 6
N. Goldstein (2002)
Does the level of E-cadherin expression correlate with the primary breast carcinoma infiltration pattern and type of systemic metastases?American journal of clinical pathology, 118 3
Chun‐Wen Cheng, Pei‐Ei Wu, Jyh‐cherng Yu, Chiun-Sheng Huang, C. Yue, Cheng-Wen Wu, Chen-Yang Shen (2001)
Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumor suppressor geneOncogene, 20
S. Droufakou, V. Deshmane, R. Roylance, A. Hanby, I. Tomlinson, I. Hart (2001)
Multiple ways of silencing E‐cadherin gene expression in lobular carcinoma of the breastInternational Journal of Cancer, 92
N. Goldstein, D. Bassi, J. Watts, L. Layfield, H. Yaziji, A. Gown (2001)
E-cadherin reactivity of 95 noninvasive ductal and lobular lesions of the breast. Implications for the interpretation of problematic lesions.American journal of clinical pathology, 115 4
Y. Kanai, T. Oda, H. Tsuda, A. Ochiai, S. Hirohashi (1994)
Point Mutation of the E–Cadherin Gene in Invasive Lobular Carcinoma of the BreastJapanese Journal of Cancer Research : Gann, 85
Haixin Lei, Sara Sjöberg-Margolin, S. Salahshor, B. Werelius, E. Jandáková, K. Hemminki, A. Lindblom, I. Vořechovský (2002)
CDH1 mutations are present in both ductal and lobular breast cancer, but promoter allelic variants show no detectable breast cancer riskInternational Journal of Cancer, 98
G. Bratthauer, F. Moinfar, M. Stamatakos, Thomas Mezzetti, K. Shekitka, Y. Man, F. Tavassoli (2002)
Combined E-cadherin and high molecular weight cytokeratin immunoprofile differentiates lobular, ductal, and hybrid mammary intraepithelial neoplasias.Human pathology, 33 6
D. Sarrió, B. Pérez-Mies, D. Hardisson, G. Moreno-Bueno, A. Suárez, A. Cano, J. Martín-Pérez, C. Gamallo, J. Palacios (2004)
Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesionsOncogene, 23
H. Shiozaki, J. Gofuku, M. Inoue, S. Tamura (1995)
[Correlation between the intercellular adhesion molecule (E-cadherin) and its associated protein (alpha-catenin) expression and metastasis in human digestive cancers].Nihon rinsho. Japanese journal of clinical medicine, 53 7
Xinyu Chen, S. Kojima, G. Borisy, K. Green (2003)
p120 catenin associates with kinesin and facilitates the transport of cadherin–catenin complexes to intercellular junctionsThe Journal of Cell Biology, 163
T. Nishizaki, K. Chew, L. Chu, J. Isola, A. Kallioniemi, N. Weidner, F. Waldman (1997)
Genetic alterations in lobular breast cancer by comparative genomic hybridizationInternational Journal of Cancer, 74
D. Gupta, C. Croitoru, A. Ayala, A. Sahin, L. Middleton (2002)
E-cadherin immunohistochemical analysis of histiocytoid carcinoma of the breast.Annals of diagnostic pathology, 6 3
D. Rimm, John Sinard, Jon Morrow (1995)
Reduced alpha-catenin and E-cadherin expression in breast cancer.Laboratory investigation; a journal of technical methods and pathology, 72 5
A. Kowalczyk, A. Reynolds (2004)
Protecting your tail: regulation of cadherin degradation by p120-catenin.Current opinion in cell biology, 16 5
C. Charpin, S. Garcia, P. Bonnier, F. Martini, L. Andrac, R. Choux, M. Lavaut, C. Allasia (1998)
Reduced E-cadherin immunohistochemical expression in node-negative breast carcinomas correlates with 10-year survival.American journal of clinical pathology, 109 4
T. Jacobs, N. Pliss, George Kouria, S. Schnitt (2001)
Carcinomas In Situ of the Breast With Indeterminate Features: Role of E-Cadherin Staining in CategorizationThe American Journal of Surgical Pathology, 25
Huiping Chen, J. Sigurgeirsdóttir, J. Jónasson, G. Eiriksdottir, J. Johannsdottir, V. Egilsson, S. Ingvarsson (1999)
Chromosome alterations and E-cadherin gene mutations in human lobular breast cancerBritish Journal of Cancer, 81
J. Reis-Filho, P. Simpson, Chris Jones, D. Steele, A. Mackay, M. Iravani, K. Fenwick, Haukur Valgeirsson, Maryou Lambros, A. Ashworth, J. Palacios, F. Schmitt, S. Lakhani (2005)
Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entityThe Journal of Pathology, 207
A. Wahed, J. Connelly, T. Reese (2002)
E-cadherin expression in pleomorphic lobular carcinoma: an aid to differentiation from ductal carcinoma.Annals of diagnostic pathology, 6 6
S. Nass, J. Herman, E. Gabrielson, P. Iversen, F. Parl, N. Davidson, J. Graff (2000)
Aberrant methylation of the estrogen receptor and E-cadherin 5' CpG islands increases with malignant progression in human breast cancer.Cancer research, 60 16
Noel Weidner, Noel Weidner, Joseph Semple, Joseph Semple (1992)
Pleomorphic variant of invasive lobular carcinoma of the breast.Human pathology, 23 10
K. Ásgeirsson, J. Jónasson, L. Tryggvadottir, K. Ólafsdóttir, J. Sigurgeirsdóttir, S. Ingvarsson, H. Ogmundsdottir (1999)
Altered expression of E-cadherin in breast cancer. patterns, mechanisms and clinical significance.European journal of cancer, 36 9
J. Klingelhöfer, R. Troyanovsky, O. Laur, S. Troyanovsky (2003)
Exchange of catenins in cadherin–catenin complexOncogene, 22
J. Hengel, P. Vanhoenacker, K. Staes, F. Roy (1999)
Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression.Proceedings of the National Academy of Sciences of the United States of America, 96 14
W. Leeuw, G. Berx, C. Vos, J. Peterse, M. Vijver, S. Litvinov, F. Roy, C. Cornelisse, A. Cleton-Jansen (1997)
Simultaneous loss of E‐cadherin and catenins in invasive lobular breast cancer and lobular carcinoma in situThe Journal of Pathology, 183
A. Reynolds, Agnes Roczniak-Ferguson (2004)
Emerging roles for p120-catenin in cell adhesion and cancerOncogene, 23
M. Esteller (2000)
Epigenetic lesions causing genetic lesions in human cancer: promoter hypermethylation of DNA repair genes.European journal of cancer, 36 18
J. Etzell, S. Devries, K. Chew, Carmina Florendo, A. Molinaro, B. Ljung, F. Waldman (2001)
Loss of chromosome 16q in lobular carcinoma in situ.Human pathology, 32 3
H. Lehr, A. Folpe, H. Yaziji, F. Kommoss, A. Gown (2000)
Cytokeratin 8 immunostaining pattern and E-cadherin expression distinguish lobular from ductal breast carcinoma.American journal of clinical pathology, 114 2
R. Bässler, H. Kronsbein (1980)
Disseminated lobular carcinoma - a predominantly pleomorphic lobular carcinoma of the whole breast.Pathology, research and practice, 166 4
N. Golenhofen, D. Drenckhahn (2000)
The catenin, p120ctn, is a common membrane-associated protein in various epithelial and non-epithelial cells and tissuesHistochemistry and Cell Biology, 114
P. Anastasiadis, A. Reynolds (2000)
The p120 catenin family: complex roles in adhesion, signaling and cancer.Journal of cell science, 113 ( Pt 8)
S. Siitonen, J. Kononen, H. Helin, I. Rantala, K. Holli, J. Isola (1996)
Reduced E-cadherin expression is associated with invasiveness and unfavorable prognosis in breast cancer.American journal of clinical pathology, 105 4
G. Acs, T. Lawton, T. Rebbeck, V. Livolsi, Paul Zhang (2001)
Differential expression of E-cadherin in lobular and ductal neoplasms of the breast and its biologic and diagnostic implications.American journal of clinical pathology, 115 1
G. Berx, A. Cleton-Jansen, K. Strumane, de Wj, F. Nollet, F. Vanroy, C. Cornelisse (1996)
E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain.Oncogene, 13 9
Watson (2001)
Regulation of blastocyst formationFront Biosci, 6
R. Hazan, L. Norton (1998)
The Epidermal Growth Factor Receptor Modulates the Interaction of E-cadherin with the Actin Cytoskeleton*The Journal of Biological Chemistry, 273
R. Yoshida, N. Kimura, Y. Harada, N. Ohuchi (2001)
The loss of E-cadherin, alpha- and beta-catenin expression is associated with metastasis and poor prognosis in invasive breast cancer.International journal of oncology, 18 3
T. Shibata, A. Kokubu, S. Sekine, Y. Kanai, S. Hirohashi (2004)
Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer.The American journal of pathology, 164 6
Sneige (2002)
Clinical, histopathologic, and biologic features of pleomorphic lobular (ductal-lobular) carcinoma in situ of the breast: a report of 24 casesMod Pathol, 15
V. Eusebi, V. Eusebi, V. Eusebi, F. Magalhães, F. Magalhaes, F. Magalhaes, J. Azzopardi, J. Azzopardi, J. Azzopardi (1992)
Pleomorphic lobular carcinoma of the breast: an aggressive tumor showing apocrine differentiation.Human pathology, 23 6
M. Gonzalez, S. Pinder, P. Wencyk, J. Bell, C. Elston, R. Nicholson, J. Robertson, R. Blamey, I. Ellis (1999)
An immunohistochemical examination of the expression of E‐cadherin, α‐ and β/γ‐catenins, and α2‐ and β1‐integrins in invasive breast cancerThe Journal of Pathology, 187
C. Vallorosi, K. Day, Xin Zhao, M. Rashid, M. Rubin, Keith Johnson, M. Wheelock, M. Day (2000)
Truncation of the β-Catenin Binding Domain of E-cadherin Precedes Epithelial Apoptosis during Prostate and Mammary Involution*The Journal of Biological Chemistry, 275
RESEARCH ARTICLE The Spectrum of Morphomolecular Abnormalities of the E-Cadherin/Catenin Complex in Pleomorphic Lobular Carcinoma of the Breast David J. Dabbs, MD, Malathy Kaplai, MD, Mamatha Chivukula, MD, Anisa Kanbour, MD, Amal Kanbour-Shakir, MD, PhD, and Gloria J. Carter, MD high nuclear grade and dyscohesive infiltrating and in situ Abstract: Pleomorphic lobular carcinoma of the breast is a high patterns. nuclear grade variant of lobular carcinoma. E-cadherin, a E-cadherin, an invasion suppressor gene, codes for a tumor-invasion suppressor gene, codes for a transmembrane transmembrane protein that functions in intercellular protein that functions in intercellular adhesion. The E-cadherin adhesion. The E-cadherin protein internal domain binds protein internal domain binds with a, b, g, and p120 catenins to with a, b, g, and p120 catenins to anchor the E-cadherin anchor the E-cadherin complex to the actin cytoskeleton of the complex to the actin cytoskeleton of the cell. The E- cell. The E-cadherin gene is routinely mutated in lobular cadherin gene is routinely mutated in lobular neoplasia, neoplasia. This study examines the morphomolecular spectrum resulting in absence of the extracellular E-cadherin of the components of the E-cadherin-catenin complex in lobular domain and lack of membrane immunostaining for the 6–17 neoplasia. Fifteen cases
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Sep 1, 2007
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.