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The Significance of Ki-67 Proliferative Index and Cyclin D1 Expression of Dysplastic Nevi in the Biologic Spectrum of Melanocytic Lesions

The Significance of Ki-67 Proliferative Index and Cyclin D1 Expression of Dysplastic Nevi in the... RESEARCH ARTICLE The Significance of Ki-67 Proliferative Index and Cyclin D1 Expression of Dysplastic Nevi in the Biologic Spectrum of Melanocytic Lesions Banu Lebe, MD, Ug˘ur Pabuc¸c¸uog˘lu, MD, and Erdener Ozer, MD esearchers investigating the significance of precursors Abstract: Familial acquired dysplastic nevi carry a risk for the Rof melanocytic lesions in the progression of melano- development of melanoma. However, the results in various mas have been of great interest. Skender-Kalnesas et al studies regarding the significance of sporadic dysplastic nevi emphasized the role of benign melanocytic lesions as as a precursor of malignant melanoma (MM), are controversial. precursors or risk markers for the development of The aim of this study is to investigate cyclin D1 expression malignant melanoma (MM) using histopathologic criteria and Ki67 proliferative index in a group of melanocytic lesions and suggested that common melanocytic nevus (CMN) to address the biologic significance of sporadic dysplastic and dysplastic nevus (DN) are precursors of skin nevi in the progression of melanocytic lesions. Formalin-fixed melanomas in approximately half of the cases. Familial paraffin-embedded material from 21 common melanocytic acquired dysplastic nevi seen in the DN syndrome carry a nevi, 42 dysplastic nevi, and 17 primary cutaneous MMs risk for http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

The Significance of Ki-67 Proliferative Index and Cyclin D1 Expression of Dysplastic Nevi in the Biologic Spectrum of Melanocytic Lesions

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ISSN
1541-2016
DOI
10.1097/01.pai.0000209868.58699.64
pmid
17525627
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE The Significance of Ki-67 Proliferative Index and Cyclin D1 Expression of Dysplastic Nevi in the Biologic Spectrum of Melanocytic Lesions Banu Lebe, MD, Ug˘ur Pabuc¸c¸uog˘lu, MD, and Erdener Ozer, MD esearchers investigating the significance of precursors Abstract: Familial acquired dysplastic nevi carry a risk for the Rof melanocytic lesions in the progression of melano- development of melanoma. However, the results in various mas have been of great interest. Skender-Kalnesas et al studies regarding the significance of sporadic dysplastic nevi emphasized the role of benign melanocytic lesions as as a precursor of malignant melanoma (MM), are controversial. precursors or risk markers for the development of The aim of this study is to investigate cyclin D1 expression malignant melanoma (MM) using histopathologic criteria and Ki67 proliferative index in a group of melanocytic lesions and suggested that common melanocytic nevus (CMN) to address the biologic significance of sporadic dysplastic and dysplastic nevus (DN) are precursors of skin nevi in the progression of melanocytic lesions. Formalin-fixed melanomas in approximately half of the cases. Familial paraffin-embedded material from 21 common melanocytic acquired dysplastic nevi seen in the DN syndrome carry a nevi, 42 dysplastic nevi, and 17 primary cutaneous MMs risk for

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jun 1, 2007

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