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The Significance of Immunohistochemical Expression of Merlin, Ki-67, and p53 in Meningiomas

The Significance of Immunohistochemical Expression of Merlin, Ki-67, and p53 in Meningiomas RESEARCH ARTICLE The Significance of Immunohistochemical Expression of Merlin, Ki-67, and p53 in Meningiomas Sanda Pavelin, MD, MSc,* Kristijan Becˇic´,MD,w Gea Forempoher, MD, PhD,z Snjezˇana Tomic´, MD, PhD,z Vesna Capkun, BSc, Dipl. Ing,y Irena Drmic´-Hofman, PhD,z Ivana Mrklic´,MD,z Ivo Lusˇic´, MD, PhD,* and Zenon Pogorelic´, MD, PhD8 eningiomas are common tumors of the central Abstract: Meningiomas are one of the most common CNS tu- Mnervous system that originate from the meningeal mors whose appearance is closely linked to NF2 gene product coverings of the brain and the spinal cord. They account merlin. Tumor markers Ki-67 and p53 play established role in for about 30% of all primary brain tumors with an ad- tumor progression which should be analyzed in close association justed annual incidence of about 4 to 5 per 100,000 in- with merlin expression. The aim of this study was to investigate dividuals, most commonly reported in elderly patients 1–3 the immunohistochemical expression of merlin in meningiomas, with peak incidence in the seventh decade of life. correlation with Ki-67 and p53, and to determine the association Meningioma initiation is closely linked to the inactivation of these results with histologic grade and subtype. The histologic of one of the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

The Significance of Immunohistochemical Expression of Merlin, Ki-67, and p53 in Meningiomas

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Copyright
Copyright © 2013 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e318289f490
pmid
23455188
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE The Significance of Immunohistochemical Expression of Merlin, Ki-67, and p53 in Meningiomas Sanda Pavelin, MD, MSc,* Kristijan Becˇic´,MD,w Gea Forempoher, MD, PhD,z Snjezˇana Tomic´, MD, PhD,z Vesna Capkun, BSc, Dipl. Ing,y Irena Drmic´-Hofman, PhD,z Ivana Mrklic´,MD,z Ivo Lusˇic´, MD, PhD,* and Zenon Pogorelic´, MD, PhD8 eningiomas are common tumors of the central Abstract: Meningiomas are one of the most common CNS tu- Mnervous system that originate from the meningeal mors whose appearance is closely linked to NF2 gene product coverings of the brain and the spinal cord. They account merlin. Tumor markers Ki-67 and p53 play established role in for about 30% of all primary brain tumors with an ad- tumor progression which should be analyzed in close association justed annual incidence of about 4 to 5 per 100,000 in- with merlin expression. The aim of this study was to investigate dividuals, most commonly reported in elderly patients 1–3 the immunohistochemical expression of merlin in meningiomas, with peak incidence in the seventh decade of life. correlation with Ki-67 and p53, and to determine the association Meningioma initiation is closely linked to the inactivation of these results with histologic grade and subtype. The histologic of one of the

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jan 1, 2014

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