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The Role of Fine Needle Aspiration Cytology in the Diagnosis and Management of Thymic Neoplasia

The Role of Fine Needle Aspiration Cytology in the Diagnosis and Management of Thymic Neoplasia MALIGNANCIES OF THE THYMUS The Role of Fine Needle Aspiration Cytology in the Diagnosis and Management of Thymic Neoplasia Maureen F. Zakowski, MD, James Huang, MD, and Matthew P. Bramlage, MD phasis on the accuracy and usefulness of cytology in the Background: Fine needle aspiration biopsy is commonly used to diagnosis and management of thymic epithelial tumors. document the metastasis to the mediastinum. It is less often used to Thymoma is a distinctive biphasic tumor containing make the primary diagnosis of tumors, particularly thymic neo- neoplastic epithelial cells and benign reactive, immature plasms. This is due to fear of sampling error, rarity of thymic T-cell lymphocytes; it is the most common primary malig- tumors, multiplicity of lesions in the mediastinum, and inexperience 1,2 nancy of the anterior mediastinum, although it can occur in on the part of the cytopathologist. We show that needle aspiration other compartments and anatomic sites as well. The possibil- sampling of thymic tumors, both thymoma and thymic carcinoma, is ity of thymoma should be considered in any patient present- an accurate method of diagnosis. ing with a mediastinal mass. Thymomas are slow growing Methods and Results: In our series of 22 thymic tumors aspirated tumors http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

The Role of Fine Needle Aspiration Cytology in the Diagnosis and Management of Thymic Neoplasia

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1556-0864

Abstract

MALIGNANCIES OF THE THYMUS The Role of Fine Needle Aspiration Cytology in the Diagnosis and Management of Thymic Neoplasia Maureen F. Zakowski, MD, James Huang, MD, and Matthew P. Bramlage, MD phasis on the accuracy and usefulness of cytology in the Background: Fine needle aspiration biopsy is commonly used to diagnosis and management of thymic epithelial tumors. document the metastasis to the mediastinum. It is less often used to Thymoma is a distinctive biphasic tumor containing make the primary diagnosis of tumors, particularly thymic neo- neoplastic epithelial cells and benign reactive, immature plasms. This is due to fear of sampling error, rarity of thymic T-cell lymphocytes; it is the most common primary malig- tumors, multiplicity of lesions in the mediastinum, and inexperience 1,2 nancy of the anterior mediastinum, although it can occur in on the part of the cytopathologist. We show that needle aspiration other compartments and anatomic sites as well. The possibil- sampling of thymic tumors, both thymoma and thymic carcinoma, is ity of thymoma should be considered in any patient present- an accurate method of diagnosis. ing with a mediastinal mass. Thymomas are slow growing Methods and Results: In our series of 22 thymic tumors aspirated tumors

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Oct 1, 2010

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