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The Role of Cytotoxic and Regulatory T cells in Relapsed/Refractory Hodgkin Lymphoma

The Role of Cytotoxic and Regulatory T cells in Relapsed/Refractory Hodgkin Lymphoma RESEARCH ARTICLE The Role of Cytotoxic and Regulatory T cells in Relapsed/Refractory Hodgkin Lymphoma Aashiyana F. Koreishi, MD,* Adam J. Saenz, MD,w Dan O. Persky, MD,z Hayan Cui, PhD,z Allison Moskowitz, MD,y Craig H. Moskowitz, MD,y and Julie Teruya-Feldstein, MD* however, one report studied only 4 cases of relapsed Abstract: Recent data suggests the presence of cytotoxic biopsies. The use of tissue microarrays (TMAs) has been 10–12 (TIA-1 and granzyme B+) and regulatory T-cells (FOXP3+) used in the study of cHL and we were therefore in classical Hodgkin lymphoma (cHL) tissues has been shown interested in analyzing expression of these markers for to correlate with poor overall survival in mainly diagnostic specific cell types in the inflammatory background in a biopsies. By tissue microarray analyses, we extend this observa- larger series of relapsed/refractory cHL biopsies to tion to a cohort of relapsed/refractory cHL tissue biopsies and determine whether there was any correlation with clinical analyze immunohistochemical expression of FOXP3, TIA-1, factors and survival outcome. and granzyme B in the inflammatory background and the tumor microenvironment. High expression of TIA-1 (>50%) corre- lated with poor overall survival (P<0.0001), low expression of MATERIALS AND METHODS FOXP3 (<25%) correlated with poor overall http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

The Role of Cytotoxic and Regulatory T cells in Relapsed&sol;Refractory Hodgkin Lymphoma

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1541-2016

Abstract

RESEARCH ARTICLE The Role of Cytotoxic and Regulatory T cells in Relapsed/Refractory Hodgkin Lymphoma Aashiyana F. Koreishi, MD,* Adam J. Saenz, MD,w Dan O. Persky, MD,z Hayan Cui, PhD,z Allison Moskowitz, MD,y Craig H. Moskowitz, MD,y and Julie Teruya-Feldstein, MD* however, one report studied only 4 cases of relapsed Abstract: Recent data suggests the presence of cytotoxic biopsies. The use of tissue microarrays (TMAs) has been 10–12 (TIA-1 and granzyme B+) and regulatory T-cells (FOXP3+) used in the study of cHL and we were therefore in classical Hodgkin lymphoma (cHL) tissues has been shown interested in analyzing expression of these markers for to correlate with poor overall survival in mainly diagnostic specific cell types in the inflammatory background in a biopsies. By tissue microarray analyses, we extend this observa- larger series of relapsed/refractory cHL biopsies to tion to a cohort of relapsed/refractory cHL tissue biopsies and determine whether there was any correlation with clinical analyze immunohistochemical expression of FOXP3, TIA-1, factors and survival outcome. and granzyme B in the inflammatory background and the tumor microenvironment. High expression of TIA-1 (>50%) corre- lated with poor overall survival (P<0.0001), low expression of MATERIALS AND METHODS FOXP3 (<25%) correlated with poor overall

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: May 1, 2010

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