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The New Taxonomy of Lung Adenocarcinoma Stemming from a Multidisciplinary Integrated Approach Novel Pathology Concepts and Perspectives

The New Taxonomy of Lung Adenocarcinoma Stemming from a Multidisciplinary Integrated Approach... EDITORIAL The New Taxonomy of Lung Adenocarcinoma Stemming from a Multidisciplinary Integrated Approach Novel Pathology Concepts and Perspectives Giuseppe Pelosi, MD, MIAC ung cancer is the leading cause of morbidity and death all over the world and a Lsignificant burden on healthcare resources of most countries. Among the diverse histologic subtypes, adenocarcinoma (AD) is the most common type of lung cancer in both males and females in most countries, even in young people, and in tumors detected 3,4 in screening low-dose computed tomography programs. The characteristic mixture of multiple subtypes has been a major source of inconsistency in subclassification in the past, hence the axiom, the more tumor categories, the more difficulties in the diagnosis. Therefore, new diagnostic criteria and uniform and consistent terminology are needed to improve accuracy and permit correlations between pathology and multiple patient char- acteristics including clinical features, tumor staging, molecular signatures, prognostic and predictive markers, and imaging data. Morphology still remains an agreed-on gold standard for AD, but a global rethinking of its histopathologic basis by exploiting an integrated multidisciplinary approach could really improve our diagnostic, prognostic, and predictive capabilities. The issue of accurate subtyping of poorly differentiated tumors and limited diagnostic material for http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

The New Taxonomy of Lung Adenocarcinoma Stemming from a Multidisciplinary Integrated Approach Novel Pathology Concepts and Perspectives

Journal of Thoracic Oncology , Volume 6 (2) – Feb 1, 2011

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References (24)

ISSN
1556-0864
DOI
10.1097/JTO.0b013e31820bfcba
pmid
21252715
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL The New Taxonomy of Lung Adenocarcinoma Stemming from a Multidisciplinary Integrated Approach Novel Pathology Concepts and Perspectives Giuseppe Pelosi, MD, MIAC ung cancer is the leading cause of morbidity and death all over the world and a Lsignificant burden on healthcare resources of most countries. Among the diverse histologic subtypes, adenocarcinoma (AD) is the most common type of lung cancer in both males and females in most countries, even in young people, and in tumors detected 3,4 in screening low-dose computed tomography programs. The characteristic mixture of multiple subtypes has been a major source of inconsistency in subclassification in the past, hence the axiom, the more tumor categories, the more difficulties in the diagnosis. Therefore, new diagnostic criteria and uniform and consistent terminology are needed to improve accuracy and permit correlations between pathology and multiple patient char- acteristics including clinical features, tumor staging, molecular signatures, prognostic and predictive markers, and imaging data. Morphology still remains an agreed-on gold standard for AD, but a global rethinking of its histopathologic basis by exploiting an integrated multidisciplinary approach could really improve our diagnostic, prognostic, and predictive capabilities. The issue of accurate subtyping of poorly differentiated tumors and limited diagnostic material for

Journal

Journal of Thoracic OncologyWolters Kluwer Health

Published: Feb 1, 2011

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