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The Multidisciplinary Approach to Thymoma Combining Molecular and Clinical Approaches

The Multidisciplinary Approach to Thymoma Combining Molecular and Clinical Approaches MALIGNANCIES OF THE THYMUS The Multidisciplinary Approach to Thymoma Combining Molecular and Clinical Approaches Nicole G. Chau, MD,* Edward S. Kim, MD,† and Ignacio Wistuba, MD‡ factor [VEGF]), and tumor invasion factors (matrix metallopro- Abstract: Thymomas are rare epithelial tumors that display signif- teinases and tissue inhibitor of metalloproteinases); however, icant heterogeneity. Thymomas are usually indolent; however, thy- these findings have yet to affect clinical practice. mic carcinomas are typically invasive with a high risk of relapse and Molecular profiling analyses at the DNA level using death. Current treatment approaches are primarily based on clinical comparative genomic hybridization have confirmed a distinc- stage. Surgery is the mainstay for treatment of early stage disease, tion between WHO types A to B2 versus type B3 and thymic whereas multimodality therapy is required for advanced disease. The 5–7 carcinomas. Furthermore, mRNA expression analysis us- most important prognostic factors are stage and histology; however, ing reverse-transcriptase polymerase chain reaction has iden- increasing recognition of disease heterogeneity has led to recent tified two genes (c-JUN and AL050002 [an unknown gene]) exploration of underlying molecular mechanisms. Molecular char- at higher levels in advanced-stage thymomas. The biologic acterization of thymic tumors may offer strategies to improve http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

The Multidisciplinary Approach to Thymoma Combining Molecular and Clinical Approaches

Wistuba, Ignacio
Journal of Thoracic Oncology , Volume 5 – Oct 1, 2010
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ISSN
1556-0864

Abstract

MALIGNANCIES OF THE THYMUS The Multidisciplinary Approach to Thymoma Combining Molecular and Clinical Approaches Nicole G. Chau, MD,* Edward S. Kim, MD,† and Ignacio Wistuba, MD‡ factor [VEGF]), and tumor invasion factors (matrix metallopro- Abstract: Thymomas are rare epithelial tumors that display signif- teinases and tissue inhibitor of metalloproteinases); however, icant heterogeneity. Thymomas are usually indolent; however, thy- these findings have yet to affect clinical practice. mic carcinomas are typically invasive with a high risk of relapse and Molecular profiling analyses at the DNA level using death. Current treatment approaches are primarily based on clinical comparative genomic hybridization have confirmed a distinc- stage. Surgery is the mainstay for treatment of early stage disease, tion between WHO types A to B2 versus type B3 and thymic whereas multimodality therapy is required for advanced disease. The 5–7 carcinomas. Furthermore, mRNA expression analysis us- most important prognostic factors are stage and histology; however, ing reverse-transcriptase polymerase chain reaction has iden- increasing recognition of disease heterogeneity has led to recent tified two genes (c-JUN and AL050002 [an unknown gene]) exploration of underlying molecular mechanisms. Molecular char- at higher levels in advanced-stage thymomas. The biologic acterization of thymic tumors may offer strategies to improve

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Oct 1, 2010

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