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The investigation of asthma phenotypes

The investigation of asthma phenotypes a,b c,d,e,f Vale´rie Siroux and Judith Garcia-Aymerich a b INSERM, U823, Universite´ Joseph Fourier, Grenoble, Purpose of review France, Centre for Research in Environmental Asthma is a heterogeneous disease constituted by overlapping separate syndromes. Epidemiology (CREAL), Hospital del Mar Research Institute (IMIM), Department of Experimental This review discusses recent published data relevant to asthma and severe asthma Sciences and Health, Universitat Pompeu Fabra and classification, resting either on the ‘candidate’ approach based on criteria chosen by CIBER en Epidemiologia y Salud Pu´blica (CIBERESP), Barcelona, Spain experts or on the ‘exploratory’ approach based on unsupervised statistical methods. Recent findings Correspondence to Vale´ rie Siroux, Centre de Recherche INSERM/UJF U823, Institut Albert Following the ‘candidate’ approach, groups of experts recently reviewed the Bonniot, BP 170, 38042 Grenoble Cedex 9, France classification of severe asthma to be applicable in low-income, milddle-income, and Tel: +33 0 4 76 54 95 56; fax: +33 0 4 76 54 94 13; e-mail: valerie.siroux@ujf-grenoble.fr high-income countries and provided a systematic algorithm to diagnose severe refractory asthma. The concept of asthma endotypes involving different biological Current Opinion in Allergy and Clinical Immunology 2011, 11:393–399 mechanisms has recently being proposed. Results from the ‘exploratory’ approach support the clinical http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Allergy and Clinical Immunology Wolters Kluwer Health

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Copyright
Copyright © Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited.
ISSN
1528-4050
eISSN
1473-6322
DOI
10.1097/ACI.0b013e32834a955a
pmid
21841473
Publisher site
See Article on Publisher Site

Abstract

a,b c,d,e,f Vale´rie Siroux and Judith Garcia-Aymerich a b INSERM, U823, Universite´ Joseph Fourier, Grenoble, Purpose of review France, Centre for Research in Environmental Asthma is a heterogeneous disease constituted by overlapping separate syndromes. Epidemiology (CREAL), Hospital del Mar Research Institute (IMIM), Department of Experimental This review discusses recent published data relevant to asthma and severe asthma Sciences and Health, Universitat Pompeu Fabra and classification, resting either on the ‘candidate’ approach based on criteria chosen by CIBER en Epidemiologia y Salud Pu´blica (CIBERESP), Barcelona, Spain experts or on the ‘exploratory’ approach based on unsupervised statistical methods. Recent findings Correspondence to Vale´ rie Siroux, Centre de Recherche INSERM/UJF U823, Institut Albert Following the ‘candidate’ approach, groups of experts recently reviewed the Bonniot, BP 170, 38042 Grenoble Cedex 9, France classification of severe asthma to be applicable in low-income, milddle-income, and Tel: +33 0 4 76 54 95 56; fax: +33 0 4 76 54 94 13; e-mail: valerie.siroux@ujf-grenoble.fr high-income countries and provided a systematic algorithm to diagnose severe refractory asthma. The concept of asthma endotypes involving different biological Current Opinion in Allergy and Clinical Immunology 2011, 11:393–399 mechanisms has recently being proposed. Results from the ‘exploratory’ approach support the clinical

Journal

Current Opinion in Allergy and Clinical ImmunologyWolters Kluwer Health

Published: Oct 1, 2011

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