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The Family of β-Catenin Ovarian Tumors

The Family of β-Catenin Ovarian Tumors LETTERS TO THE EDITOR The Family of b-Catenin TABLE 1. Summary of the Main Morphologic, Immunohistochemical, and Molecular Features of Solid-Pseudopapillary Neoplasm, Microcystic Stromal Tumor and Ovarian Tumors Signet-Ring Stromal Cell Tumor of the Ovary, the “b-Catenin Family” of Ovarian Neoplasm Solid- Pattern of growth: solid, b-catenin+(nuclear Exon 3 mutation of To the Editor: pseudopapil- pseudopapillary and microcystic and cytoplasmic) ctnnb1 (ref #3) lary neoplasm Cytology: cells with abundant CD56 Mutational We read with great interest the 1 eosinophilic cytoplasm with CD10 activation of the work by Kopczynski et al’s who de- intracytoplasmic vacuoles and CD117 Wnt/b-catenin tected, for the first time, oncogenic uniform round nuclei Cyclin D1+ pathway activation of the Wnt/b-catenin sig- Cytokeratin– naling pathway in a signet-ring stro- E-cadherin– Inhibin– mal cell tumor (SRSCT) of the ovary. Calretinin– b-catenin belongs to the Wnt signal- Little or no mitotic ing pathway, and mutation of exon 3 activity of ctnnb1 is often related to the nu- Microcystic Pattern of growth: microcystic, and b-catenin+(nuclear Exon 3 mutation of stromal tumor solid and cytoplasmic) ctnnb1 (57%- clear translocation of the protein, re- Cytology: cells with moderate CD10 77.8%) sulting in a peculiar positive nuclear amount of finely granular, lightly E-cadherin+ http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

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References (6)

Publisher
Wolters Kluwer Health
Copyright
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1062-3345
eISSN
1533-4058
DOI
10.1097/PAI.0000000000000480
pmid
27941568
Publisher site
See Article on Publisher Site

Abstract

LETTERS TO THE EDITOR The Family of b-Catenin TABLE 1. Summary of the Main Morphologic, Immunohistochemical, and Molecular Features of Solid-Pseudopapillary Neoplasm, Microcystic Stromal Tumor and Ovarian Tumors Signet-Ring Stromal Cell Tumor of the Ovary, the “b-Catenin Family” of Ovarian Neoplasm Solid- Pattern of growth: solid, b-catenin+(nuclear Exon 3 mutation of To the Editor: pseudopapil- pseudopapillary and microcystic and cytoplasmic) ctnnb1 (ref #3) lary neoplasm Cytology: cells with abundant CD56 Mutational We read with great interest the 1 eosinophilic cytoplasm with CD10 activation of the work by Kopczynski et al’s who de- intracytoplasmic vacuoles and CD117 Wnt/b-catenin tected, for the first time, oncogenic uniform round nuclei Cyclin D1+ pathway activation of the Wnt/b-catenin sig- Cytokeratin– naling pathway in a signet-ring stro- E-cadherin– Inhibin– mal cell tumor (SRSCT) of the ovary. Calretinin– b-catenin belongs to the Wnt signal- Little or no mitotic ing pathway, and mutation of exon 3 activity of ctnnb1 is often related to the nu- Microcystic Pattern of growth: microcystic, and b-catenin+(nuclear Exon 3 mutation of stromal tumor solid and cytoplasmic) ctnnb1 (57%- clear translocation of the protein, re- Cytology: cells with moderate CD10 77.8%) sulting in a peculiar positive nuclear amount of finely granular, lightly E-cadherin+

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Nov 1, 2017

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