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R. Bi, Q. Bai, Fei Yang, Lijing Wu, Yufan Cheng, Xuxia Shen, Xu Cai, Xiao‐yan Zhou, Wentao Yang (2015)
Microcystic stromal tumour of the ovary: frequent mutations of β‐catenin (CTNNB1) in six casesHistopathology, 67
Qin Chen, W. Lu, W. Lv (2015)
Overlap of microcystic stromal tumor and primary solid pseudopapillary neoplasm of the ovary.International journal of clinical and experimental pathology, 8 9
V. Deshpande, E. Oliva, R. Young (2010)
Solid Pseudopapillary Neoplasm of the Ovary: A Report of 3 Primary Ovarian Tumors Resembling Those of the PancreasThe American Journal of Surgical Pathology, 34
J. Kopczyński, A. Kowalik, Małgorzata Chłopek, Zengfeng Wang, S. Góźdź, J. Lasota, M. Miettinen (2016)
Oncogenic Activation of the Wnt/&bgr;-Catenin Signaling Pathway in Signet Ring Stromal Cell Tumor of the OvaryApplied Immunohistochemistry & Molecular Morphology, 24
J. Irving, Cheng-Han Lee, S. Yip, E. Oliva, W. McCluggage, R. Young (2015)
Microcystic Stromal Tumor: A Distinctive Ovarian Sex Cord-Stromal Neoplasm Characterized by FOXL2, SF-1, WT-1, Cyclin D1, and &bgr;-catenin Nuclear Expression and CTNNB1 MutationsThe American Journal of Surgical Pathology, 39
Ayami Kominami, M. Fujino, H. Murakami, Masafumi Ito (2014)
β‐catenin mutation in ovarian solid pseudopapillary neoplasmPathology International, 64
LETTERS TO THE EDITOR The Family of b-Catenin TABLE 1. Summary of the Main Morphologic, Immunohistochemical, and Molecular Features of Solid-Pseudopapillary Neoplasm, Microcystic Stromal Tumor and Ovarian Tumors Signet-Ring Stromal Cell Tumor of the Ovary, the “b-Catenin Family” of Ovarian Neoplasm Solid- Pattern of growth: solid, b-catenin+(nuclear Exon 3 mutation of To the Editor: pseudopapil- pseudopapillary and microcystic and cytoplasmic) ctnnb1 (ref #3) lary neoplasm Cytology: cells with abundant CD56 Mutational We read with great interest the 1 eosinophilic cytoplasm with CD10 activation of the work by Kopczynski et al’s who de- intracytoplasmic vacuoles and CD117 Wnt/b-catenin tected, for the first time, oncogenic uniform round nuclei Cyclin D1+ pathway activation of the Wnt/b-catenin sig- Cytokeratin– naling pathway in a signet-ring stro- E-cadherin– Inhibin– mal cell tumor (SRSCT) of the ovary. Calretinin– b-catenin belongs to the Wnt signal- Little or no mitotic ing pathway, and mutation of exon 3 activity of ctnnb1 is often related to the nu- Microcystic Pattern of growth: microcystic, and b-catenin+(nuclear Exon 3 mutation of stromal tumor solid and cytoplasmic) ctnnb1 (57%- clear translocation of the protein, re- Cytology: cells with moderate CD10 77.8%) sulting in a peculiar positive nuclear amount of finely granular, lightly E-cadherin+
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Nov 1, 2017
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