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The early origins of asthma: who is really at risk?

The early origins of asthma: who is really at risk? The early origins of asthma: who is really at risk? Peter D. Sly Deputy Director, Queensland Children’s Medical Purpose of review Research Institute, University of Queensland, Brisbane, Asthma is largely a developmental disease in which the normal development of the Australia respiratory and immune systems is altered by the impacts of environmental exposures Correspondence to Peter D. Sly, Queensland acting on underlying genetic predispositions. This review will comment on the Children’s Medical Research Institute, Level 4 Foundation Building, Royal Children’s Hospital, latest evidence in this field. Herston, Brisbane, Queensland 4029, Australia Recent findings Tel: +61 07 36365578, mobile: 61 07 36369690; fax: +61 07 36365578; e-mail: p.sly@uq.edu.au There is increasing evidence that several potentially overlapping genetic predispositions may contribute to the development of asthma, including predisposition to abnormal Current Opinion in Allergy and Clinical Immunology 2011, 11:24–28 lung growth, resulting in lower lung function; delayed immune maturation; predisposition to lower respiratory viral infections; early allergic sensitization; and predisposition to bronchial hyper-responsiveness. Networks of genes and environmental modification of gene expression via epigenetic mechanisms are also likely to be important. Antenatal exposures that increase the risk of asthma include tobacco smoke, ambient and indoor air pollution. Impacts of maternal nutrition http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Allergy and Clinical Immunology Wolters Kluwer Health

The early origins of asthma: who is really at risk?

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ISSN
1528-4050
eISSN
1473-6322
DOI
10.1097/ACI.0b013e328342309d
pmid
21150438
Publisher site
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Abstract

The early origins of asthma: who is really at risk? Peter D. Sly Deputy Director, Queensland Children’s Medical Purpose of review Research Institute, University of Queensland, Brisbane, Asthma is largely a developmental disease in which the normal development of the Australia respiratory and immune systems is altered by the impacts of environmental exposures Correspondence to Peter D. Sly, Queensland acting on underlying genetic predispositions. This review will comment on the Children’s Medical Research Institute, Level 4 Foundation Building, Royal Children’s Hospital, latest evidence in this field. Herston, Brisbane, Queensland 4029, Australia Recent findings Tel: +61 07 36365578, mobile: 61 07 36369690; fax: +61 07 36365578; e-mail: p.sly@uq.edu.au There is increasing evidence that several potentially overlapping genetic predispositions may contribute to the development of asthma, including predisposition to abnormal Current Opinion in Allergy and Clinical Immunology 2011, 11:24–28 lung growth, resulting in lower lung function; delayed immune maturation; predisposition to lower respiratory viral infections; early allergic sensitization; and predisposition to bronchial hyper-responsiveness. Networks of genes and environmental modification of gene expression via epigenetic mechanisms are also likely to be important. Antenatal exposures that increase the risk of asthma include tobacco smoke, ambient and indoor air pollution. Impacts of maternal nutrition

Journal

Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health

Published: Feb 1, 2011

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