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The Characteristics of Breast Cancer Subtypes Implications for Treatment Guidelines and Individualized Treatment Strategies in China

The Characteristics of Breast Cancer Subtypes Implications for Treatment Guidelines and... RESEARCH ARTICLE The Characteristics of Breast Cancer Subtypes: Implications for Treatment Guidelines and Individualized Treatment Strategies in China Shan Zheng, PhD,* Qing-Kun Song, PhD,w Yu Ren, PhD,z Wei-Liang Feng, MS,y Ya-Nan Kong, MS,8 Rong Huang, MS,wz Feng Xu, PhD,# Jing Li, PhD,w Bao-Ning Zhang, BS,** Jin-Hu Fan, BS,w Jian-Jun He, PhD,z and You-Lin Qiao, PhDw may give some suggestions for updating treatment guidelines and Abstract: This study aimed at investigating the characteristics of individualized treatment strategies in China. invasive breast cancer among molecular subtypes. Patients with Key Words: breast carcinoma, subtype, age, regional socio- invasive breast cancer, with complete information on the ex- economic status, nationwide pressions of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 (HER2), were recruited. w (Appl Immunohistochem Mol Morphol 2014;22:383–389) tests and an unconditional logistic regression model were used for statistical analysis. The percentages of luminal A, luminal B, HER2/neu, and triple-negative subtypes were 54.2% (1639/3021), reast cancer is one of the diseases that seriously 14.0% (422/3021), 8.9% (269/3021), and 22.9% (691/3021), re- Bthreaten women’s health. In 2008, breast cancer ac- spectively. Differences among molecular subtypes (P<0.05) in counted for 23% (1.38 million) of total cancer cases and tumor size, stage, pathologic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

The Characteristics of Breast Cancer Subtypes Implications for Treatment Guidelines and Individualized Treatment Strategies in China

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Copyright
Copyright © 2013 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e3182a3c52c
pmid
24162264
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE The Characteristics of Breast Cancer Subtypes: Implications for Treatment Guidelines and Individualized Treatment Strategies in China Shan Zheng, PhD,* Qing-Kun Song, PhD,w Yu Ren, PhD,z Wei-Liang Feng, MS,y Ya-Nan Kong, MS,8 Rong Huang, MS,wz Feng Xu, PhD,# Jing Li, PhD,w Bao-Ning Zhang, BS,** Jin-Hu Fan, BS,w Jian-Jun He, PhD,z and You-Lin Qiao, PhDw may give some suggestions for updating treatment guidelines and Abstract: This study aimed at investigating the characteristics of individualized treatment strategies in China. invasive breast cancer among molecular subtypes. Patients with Key Words: breast carcinoma, subtype, age, regional socio- invasive breast cancer, with complete information on the ex- economic status, nationwide pressions of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 (HER2), were recruited. w (Appl Immunohistochem Mol Morphol 2014;22:383–389) tests and an unconditional logistic regression model were used for statistical analysis. The percentages of luminal A, luminal B, HER2/neu, and triple-negative subtypes were 54.2% (1639/3021), reast cancer is one of the diseases that seriously 14.0% (422/3021), 8.9% (269/3021), and 22.9% (691/3021), re- Bthreaten women’s health. In 2008, breast cancer ac- spectively. Differences among molecular subtypes (P<0.05) in counted for 23% (1.38 million) of total cancer cases and tumor size, stage, pathologic

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: May 1, 2014

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