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RESEARCH ARTICLE The Challenging Diagnosis of the Rhabdoid Carcinoma of the Pelvis: A Case Report With Literature Review Maria Rosaria Raspollini, MD, PhD,* Vincenzo Li Marzi, MD,w Giulio Nicita, MD,w and Gregor Mikuz, MD, FRCPathz has been considered as a variant of Wilms tumor. Abstract: Rhabdoid tumor is an uncommon neoplasia character- Subsequently, the terminology was abbreviated to ized by a monotonous population of large, noncohesive cells with “rhabdoid tumor.” The term indicates a tumor char- vesicular nuclei and large nucleoli. The misleading name was acterized by a monotonous population of large, non- originally suggested because of the striking morphologic resem- cohesive cells with vesicular nuclei and large nucleoli. The blance to other skeletal muscle tumors, but neither ultrastructural misleading name was originally suggested because of the nor immunohistochemical features support a myogenic origin for striking morphologic resemblance to other skeletal this tumor. The rhabdoid tumors of the kidney in pediatric age muscle tumors. However, neither ultrastructural nor are characterized by mutation or deletion of 22q11. In adults, immunohistochemical investigations could prove the tumors with rhabdoid features are uncommon neoplasia reported myogenic origin of this tumor. Since the original report, in different anatomic sites, but their histogenesis is still
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Mar 1, 2012
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