Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Th17 cells in natural SIV hosts

Th17 cells in natural SIV hosts Mirko Paiardini Department of Pathology and Laboratory Medicine, Purpose of review University of Pennsylvania School of Medicine, To summarize our current understanding of the regulation of Th17 cells in pathogenic Philadelphia, USA and nonpathogenic lentiviral infections. Correspondence to Mirko Paiardini, Department of Recent findings Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 702 Stellar Chance It has been shown that Th17 cells, a recently identified T helper-cell subset deemed Laboratory, 422 Curie Blvd, PA 19104, USA critical for antimicrobial mucosal immunity, are preferentially depleted in the Tel: +1 215 573 5368; e-mail: mpaiardi@mail.med.upenn.edu gastrointestinal tracts of human immunodeficiency virus (HIV)-infected humans and simian immunodeficiency virus (SIV)-infected rhesus and pigtailed (PTMs) macaques. In Current Opinion in HIV and AIDS 2010, 5:166–172 contrast, Th17 cells are preserved at healthy levels in monkey species that are natural hosts for SIV, such as sooty mangabeys or African green monkeys (AGMs), which maintain mucosal immunity and remain AIDS free. These findings suggest that preservation of Th17 cells (or lack thereof) may be central in determining the pathogenic or nonpathogenic outcome of HIV/SIV infection. Summary A preferential depletion of mucosal Th17 cells is a feature that distinguishes pathogenic HIV infection of humans from http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Th17 cells in natural SIV hosts

Current Opinion in HIV and Aids , Volume 5 (2) – Mar 1, 2010

Loading next page...
 
/lp/wolters-kluwer-health/th17-cells-in-natural-siv-hosts-U0sNpNeO82

References (61)

ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e328335c161
pmid
20543595
Publisher site
See Article on Publisher Site

Abstract

Mirko Paiardini Department of Pathology and Laboratory Medicine, Purpose of review University of Pennsylvania School of Medicine, To summarize our current understanding of the regulation of Th17 cells in pathogenic Philadelphia, USA and nonpathogenic lentiviral infections. Correspondence to Mirko Paiardini, Department of Recent findings Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 702 Stellar Chance It has been shown that Th17 cells, a recently identified T helper-cell subset deemed Laboratory, 422 Curie Blvd, PA 19104, USA critical for antimicrobial mucosal immunity, are preferentially depleted in the Tel: +1 215 573 5368; e-mail: mpaiardi@mail.med.upenn.edu gastrointestinal tracts of human immunodeficiency virus (HIV)-infected humans and simian immunodeficiency virus (SIV)-infected rhesus and pigtailed (PTMs) macaques. In Current Opinion in HIV and AIDS 2010, 5:166–172 contrast, Th17 cells are preserved at healthy levels in monkey species that are natural hosts for SIV, such as sooty mangabeys or African green monkeys (AGMs), which maintain mucosal immunity and remain AIDS free. These findings suggest that preservation of Th17 cells (or lack thereof) may be central in determining the pathogenic or nonpathogenic outcome of HIV/SIV infection. Summary A preferential depletion of mucosal Th17 cells is a feature that distinguishes pathogenic HIV infection of humans from

Journal

Current Opinion in HIV and AidsWolters Kluwer Health

Published: Mar 1, 2010

There are no references for this article.