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The risks and benefits of drug therapy in pregnancy remain difficult to evaluate. This article, in two parts, sets out some general principles of teratogenesis and prescribing in pregnancy, lists drugs known to be fetotoxic or teratogenic, and describes the specific problems that occur with drugs acting on the central nervous system. These include facial dysmorphism and neural tube defects with anticonvulsant drugs; potential cardiac defects with lithium; and possible withdrawal syndromes with antidepressant drugs.
Adverse Drug Reaction Bulletin – Wolters Kluwer Health
Published: Apr 1, 2002
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