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RESEARCH ARTICLE Tenascin and Fibronectin Expression in Carcinoma Ex Pleomorphic Adenoma Vera Cavalcanti de Arau´jo, DDS, PhD,* Cristiane Furuse, DDS, PhD,* Patricia Ramos Cury, DDS, PhD,w Albina Altemani, MD, PhD,z Venaˆncio Avancini Ferreira Alves, MD, PhD,y and Ney Soares de Arau´jo, DDS, PhDJ arcinoma ex pleomorphic adenoma (CXPA), a rare Abstract: This study was conducted to analyze the participation Cmalignant salivary gland tumor, is an important of tenascin and fibronectin, components of the extracellular model to study the complex mechanism of tumor matrix, in different types of carcinoma ex pleomorphic adenoma malignization and progression. Our group has studied (CXPA). Seventeen cases of CXPA, classified according to the several aspects of this lesion such as cytoskeleton, presence of epithelial and myoepithelial cells and the degree of adhesion molecules, and proteins involved in cell cycle. invasion—intracapsular, minimally, and frankly invasive carci- Recently, we demonstrated by immunohistochemistry noma—were immunohistochemically labeled for tenascin and that CXPA is composed of tumors either with only fibronectin. Normal salivary gland included in the specimens epithelium differentiation or with epithelium and myoe- showed tenascin only around the excretory duct, and fibronectin pithelium. These salivary gland tumors were classified as slightly expressed all over the stroma of the
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Jan 1, 2008
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