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Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Stromal Matrix Metalloproteinase-14 Expression Correlates With the Grade and Biological Behavior of Mammary Phyllodes Tumors Ga-Eon Kim, MD,* Jo-Heon Kim, MD, PhD,w Kyung Hwa Lee, MD, PhD,* Yoo Duck Choi, MD, PhD,* Ji Shin Lee, MD, PhD,* Jae Hyuk Lee, MD, PhD,* Jong Hee Nam, MD, PhD,* Chan Choi, MD, PhD,* Min Ho Park, MD, PhD,z and Jung Han Yoon, MD, PhDz hyllodes tumors (PTs) are rare tumors characterized Abstract: Phyllodes tumors (PTs) of the breast are rare biphasic Pby a double-layered epithelial component arranged in tumors with the potential for invasion and metastatic spread. clefts, surrounded by an overgrowing hypercellular Matrix metalloproteinases (MMPs) and their tissue inhibitors of mesenchymal component, typically organized in leaf-like metalloproteinases (TIMPs) are involved in several key aspects structures. In 2003, World Health Organization divided of tumoral growth, invasion, and metastasis, but little is known breast PTs into 3 groups (benign, borderline, and of their expression in PTs. The objective of this study was malignant), depending on the stromal cellularity, cellular to assess the expression of MMPs and TIMPs in PTs and to pleomorphism, mitotic activity, margin appearance, and determine their association with grade and
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: May 1, 2012
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