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Brief Repotr Stereotactic Body Radiotherapy Using a Radiobiology-Based Regimen for Stage I Non–Small-Cell Lung Cancer Five-Year Mature Results Yuta Shibamoto, MD, PhD,* Chisa Hashizume, MD,† Fumiya Baba, MD, PhD,* Shiho Ayakawa, MD, PhD,‡ Akifumi Miyakawa, MD, PhD,* Taro Murai, MD, PhD,* Taiki Takaoka, MD,* Yukiko Hattori, MD,* and Ryuji Asai, MD, PhD§ tereotactic body radiotherapy (SBRT) is now the first Introduction: Although the protocol of 48 Gy in four fractions over Schoice of treatment for medically inoperable patients with 4 days has been most often employed in stereotactic body radiother- stage I non–small-cell lung cancer (NSCLC) and operable apy (SBRT) for stage I non–small-cell lung cancer in Japan, higher 1–3 patients who refuse surgery. Recently reported results sug- doses are necessary to control larger tumors, and interfraction inter- 4–7 gest that SBRT and surgery yield nearly equivalent outcome. vals should be longer than 24 hours to take advantage of reoxygen- Owing to the relatively short history, however, the vast major- ation. We report the final results of our study testing the following ity of previously published data of SBRT, including those in regimen: for tumors less than 1.5, 1.5–3, and greater than 3 cm in 3,7–10 very recent publications, are middle-term 3-year data. To diameter, 44, 48, and 52 Gy,
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Jun 1, 2015
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