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RESEARCH ARTICLE Stepwise Expression of CDKN2A and RB1 Proteins in Esophageal Mucosa From Patients at High Risk for Squamous Cell Carcinoma Leandro B. Muller, MD,*w Luise Meurer, MD, PhD,*z Antoˆnio Barros Lopes, MD,* Luis C.M. Antunes, MD,* Sara Vanazzi, MD,*y and Renato B. Fagundes, MD, PhD*8 sophageal cancer is the sixth leading cause of cancer Abstract: Squamous cell carcinoma of the esophagus is a lethal Edeath worldwide. Its high mortality is associated with cancer and carries a poor prognosis because of late diagnosis. late diagnosis, which reduces the chances of curative 2,3 Identification of molecular markers may aid early diagnosis. We therapy. In southern Brazil, squamous cell carcinoma assessed the expression of CDKN2A/RB1 in the esophageal of the esophagus (SCCE) accounts for almost 90% of mucosa and its association with the histology. Esophageal bi- malignancies in this organ. The main risk factors opsies were collected from 38 patients with no esophageal lesion worldwide for this cancer are tobacco and alcohol con- 5–11 (group 1), from iodine-negative areas of 108 alcoholics/smokers sumption. (group 2), and from tumor and nontumor areas in 41 patients The identification of precursor lesions found in the with squamous cell carcinoma (group 3). The histologic diag-
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Oct 1, 2014
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