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MALIGNANCIES OF THE THYMUS Akira Masaoka, MD, PhD that the predominantly epithelial subtype of thymoma was the Introduction: Thirty years have gone by since the Masaoka staging most dominant among invasive thymomas. system of thymoma was proposed in 1981. Although the Masaoka To quantify the ratio of epithelial cells and lympho- staging system has been accepted by many surgeons and patholo- cytes, we calculated the numbers of these cells and deter- gists, some proposals of revision and improvements have been mined the lymphocytes to epithelial cells ratio (L/E ratio). In suggested. At this time, I reinvestigated the Masaoka staging system our series of 22 cases, L/E ratios ranged from 0.27 to 4.10 based on the recent follow-up study of the thymomas resected at with a mean value of 1.93 (Figure 1). Nagoya City University. We also found a significant difference in the L/E ratios Methods: Using the follow-up results of 211 thymomas in Nagoya, of invasive and noninvasive thymomas (Figure 2) with inva- I analyzed the following aspects: (1) evaluation of the Masaoka sive thymomas having a lower ratio than noninvasive thymo- staging system as a prognostic factor in the Nagoya series and (2) mas. This had also been
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Oct 1, 2010
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