Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Sorting Nexin 2 (SNX2) A Potential Marker of Active Thyrocytes in Normal and Hyperfunctioning Thyroid Disorders

Sorting Nexin 2 (SNX2) A Potential Marker of Active Thyrocytes in Normal and Hyperfunctioning... RESEARCH ARTICLE Sorting Nexin 2 (SNX2): A Potential Marker of Active Thyrocytes in Normal and Hyperfunctioning Thyroid Disorders Maki Kanzawa, MD,* Shigeo Hara, MD, PhD,* Shuho Semba, MD, PhD,w Hiroshi Yokozaki, MD, PhD,w Mitsuyoshi Hirokawa, MD, PhD,z and Tomoo Itoh, MD, PhD* may be flattened, cuboidal, or columnar. A flattened Abstract: Sorting nexins (SNXs) are a large, diverse group of morphology is typical of inactive or resting follicular cells, cytoplasmic and membrane-associated proteins that function in a whereas cuboidal and columnar morphologies are typical variety of cellular processes, including endocytosis, protein traf- of active thyrocytes. Cuboidal cells secrete colloid into the ficking, and the retrieval of transmembrane proteins. In this study, lumen, whereas columnar cells resorb thyroglobulin (TG)- we demonstrated that SNX2 is expressed in columnar and active containing colloid and release active hormones into the thyroid follicular cells but not in flattened inactive thyrocytes. 1 blood stream. Active follicular cells express characteristic Morphometric analysis revealed a significant correlation between molecules involved in thyroid hormone synthesis, including SNX2 positivity and columnar cell morphology. Immunohisto- pendrin, thyroperoxidase (TPO), thyroid-stimulating hor- chemical staining of serial sections of the thyroid tissue indicated mone receptor, thyroid oxidases (ThOXs), and peroxir- 2,3 that SNX2 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Sorting Nexin 2 (SNX2) A Potential Marker of Active Thyrocytes in Normal and Hyperfunctioning Thyroid Disorders

Loading next page...
 
/lp/wolters-kluwer-health/sorting-nexin-2-snx2-a-potential-marker-of-active-thyrocytes-in-normal-umyON0o1Xh

References (24)

Copyright
Copyright © 2013 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e31828badd3
pmid
23531855
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Sorting Nexin 2 (SNX2): A Potential Marker of Active Thyrocytes in Normal and Hyperfunctioning Thyroid Disorders Maki Kanzawa, MD,* Shigeo Hara, MD, PhD,* Shuho Semba, MD, PhD,w Hiroshi Yokozaki, MD, PhD,w Mitsuyoshi Hirokawa, MD, PhD,z and Tomoo Itoh, MD, PhD* may be flattened, cuboidal, or columnar. A flattened Abstract: Sorting nexins (SNXs) are a large, diverse group of morphology is typical of inactive or resting follicular cells, cytoplasmic and membrane-associated proteins that function in a whereas cuboidal and columnar morphologies are typical variety of cellular processes, including endocytosis, protein traf- of active thyrocytes. Cuboidal cells secrete colloid into the ficking, and the retrieval of transmembrane proteins. In this study, lumen, whereas columnar cells resorb thyroglobulin (TG)- we demonstrated that SNX2 is expressed in columnar and active containing colloid and release active hormones into the thyroid follicular cells but not in flattened inactive thyrocytes. 1 blood stream. Active follicular cells express characteristic Morphometric analysis revealed a significant correlation between molecules involved in thyroid hormone synthesis, including SNX2 positivity and columnar cell morphology. Immunohisto- pendrin, thyroperoxidase (TPO), thyroid-stimulating hor- chemical staining of serial sections of the thyroid tissue indicated mone receptor, thyroid oxidases (ThOXs), and peroxir- 2,3 that SNX2

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Apr 1, 2014

There are no references for this article.