Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Soluble ST2 Is Regulated by p75 Neurotrophin Receptor and Predicts Mortality in Diabetic Patients With Critical Limb Ischemia

Soluble ST2 Is Regulated by p75 Neurotrophin Receptor and Predicts Mortality in Diabetic Patients... Soluble ST2 Is Regulated by p75 Neurotrophin Receptor and Predicts Mortality in Diabetic Patients With Critical Limb Ischemia Andrea Caporali, Marco Meloni, Ashley M. Miller, Klemens Vierlinger, Alessandro Cardinali, Gaia Spinetti, Audrey Nailor, Ezio Faglia, Sergio Losa, Ambra Gotti, Orazio Fortunato, Tijana Mitić, Manuela Hofner, Christa Noehammer, Paolo Madeddu, Costanza Emanueli NTR Objective—The p75 neurotrophin receptor (p75 ) contributes to diabetes mellitus−induced defective postischemic neovascularization. The interleukin-33 receptor ST2 is expressed as transmembrane (ST2L) and soluble (sST2) isoforms. NTR Here, we studied the following: (1) the impact of p75 in the healing of ischemic and diabetic calf wounds; (2) the link NTR between p75 and ST2; and (3) circulating sST2 levels in critical limb ischemia (CLI) patients. NTR Methods and Results—Diabetes mellitus was induced in p75 knockout (p75KO) mice and wild-type (WT) littermates by streptozotocin. Diabetic and nondiabetic p75KO and WT mice received left limb ischemia induction and a full-thickness wound on the ipsilateral calf. Diabetes mellitus impaired wound closure and angiogenesis and increased ST2 expression NTR in WT, but not in p75KO wounds. In cultured endothelial cells, p75 promoted ST2 (both isoforms) expression through MAPK p38 /activating transcription factor 2 pathway activation. Next, sST2 was measured in the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis, Thrombosis, and Vascular Biology Wolters Kluwer Health

Soluble ST2 Is Regulated by p75 Neurotrophin Receptor and Predicts Mortality in Diabetic Patients With Critical Limb Ischemia

Download PDF
12 pages

Loading next page...
 
/lp/wolters-kluwer-health/soluble-st2-is-regulated-by-p75-neurotrophin-receptor-and-predicts-7eGafFcJ9u

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Copyright
© 2012 American Heart Association, Inc.
ISSN
1079-5642
eISSN
1524-4636
DOI
10.1161/ATVBAHA.112.300497
pmid
23065828
Publisher site
See Article on Publisher Site

Abstract

Soluble ST2 Is Regulated by p75 Neurotrophin Receptor and Predicts Mortality in Diabetic Patients With Critical Limb Ischemia Andrea Caporali, Marco Meloni, Ashley M. Miller, Klemens Vierlinger, Alessandro Cardinali, Gaia Spinetti, Audrey Nailor, Ezio Faglia, Sergio Losa, Ambra Gotti, Orazio Fortunato, Tijana Mitić, Manuela Hofner, Christa Noehammer, Paolo Madeddu, Costanza Emanueli NTR Objective—The p75 neurotrophin receptor (p75 ) contributes to diabetes mellitus−induced defective postischemic neovascularization. The interleukin-33 receptor ST2 is expressed as transmembrane (ST2L) and soluble (sST2) isoforms. NTR Here, we studied the following: (1) the impact of p75 in the healing of ischemic and diabetic calf wounds; (2) the link NTR between p75 and ST2; and (3) circulating sST2 levels in critical limb ischemia (CLI) patients. NTR Methods and Results—Diabetes mellitus was induced in p75 knockout (p75KO) mice and wild-type (WT) littermates by streptozotocin. Diabetic and nondiabetic p75KO and WT mice received left limb ischemia induction and a full-thickness wound on the ipsilateral calf. Diabetes mellitus impaired wound closure and angiogenesis and increased ST2 expression NTR in WT, but not in p75KO wounds. In cultured endothelial cells, p75 promoted ST2 (both isoforms) expression through MAPK p38 /activating transcription factor 2 pathway activation. Next, sST2 was measured in the

Journal

Arteriosclerosis, Thrombosis, and Vascular Biology – Wolters Kluwer Health

Published: Dec 1, 2012

There are no references for this article.