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Anjana JTO EDITORIAL Small-Cell Lung Cancer Treatment Small-Cell Lung Cancer Treatment Yang Where is the Target? James Chih-Hsin Yang, MD, PhD hemotherapy is very effective for the treatment of small-cell lung cancer (SCLC). CDespite the initial high response rates (RR), chemotherapy is rarely curative for extended stage (ED)-SCLC patients. In contrast to the high efficacy of first-line chemo - therapy, the RR and progression-free survival of second-line treatment are very modest. Patients refractory to first-line treatments (progression during treatment) and chemotherapy (disease progression within 3 months of last chemotherapy) often gain insignificant ben - efit from second-line treatments. Sensitive relapsed SCLC patients (progression 3 months after last chemotherapy) can be retreated with the first-line regimen or switched to second- line chemotherapy. However, they only represent a small proportion of patients and they generally become refractory to the treatment. Multiple chemotherapeutic regimens have been tested in ED SCLC as first-line treatment with similar good RR, progression-free sur - vival, and overall survival (OS) outcome. A systemic review of 5530 SCLC patients treated with platinum- versus nonplatinum-based regimens showed that there were no differences in RR and 12- or 24-month survival. Currently, cisplatin and etoposide (PE) remain the most popular standard
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Sep 1, 2012
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