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Skin Homing of Treponema pallidum An Immunohistochemical Study

Skin Homing of Treponema pallidum An Immunohistochemical Study RESEARCH ARTICLE Skin Homing of Treponema pallidum in Early Syphilis An Immunohistochemical Study Pascale Quatresooz, MD, PhD and Ge´rald E. Pie´rard, MD, PhD and sequelae of the chronic stage of the disease. However, Abstract: The incidence of syphilis is increasing in most parts the clinical presentation of secondary syphilis can be of the world including some major European cities. The lesions diverse including follicular lesions as well as eruptions developing during secondary syphilis may be difficult to resembling pityriasis lichenoides and pityriasis rosea. diagnose clinically. Similarly, the histopathologic changes do Owing to the variable clinical aspects, syphilis has been not always fulfill the typical diagnostic criteria. The objective described as ‘‘the great imitator.’’ To render the situation of this study was to assess the contribution of immunohisto- more complex HIV infection can be associated with 1–4 chemistry for the identification and localization of Treponema syphilis and can affect its presentation and progression. pallidum on the skin. We retrieved from our files 12 paraffin- At the histologic examination, the diagnostic clues embedded biopsies of skin lesions, which had posed diagnostic for syphilis are not always straightforward. For instance, problems in the past. Only a serologic test had proven that the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Skin Homing of Treponema pallidum An Immunohistochemical Study

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ISSN
1541-2016
DOI
10.1097/PAI.0b013e3181788186
pmid
18800002
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Skin Homing of Treponema pallidum in Early Syphilis An Immunohistochemical Study Pascale Quatresooz, MD, PhD and Ge´rald E. Pie´rard, MD, PhD and sequelae of the chronic stage of the disease. However, Abstract: The incidence of syphilis is increasing in most parts the clinical presentation of secondary syphilis can be of the world including some major European cities. The lesions diverse including follicular lesions as well as eruptions developing during secondary syphilis may be difficult to resembling pityriasis lichenoides and pityriasis rosea. diagnose clinically. Similarly, the histopathologic changes do Owing to the variable clinical aspects, syphilis has been not always fulfill the typical diagnostic criteria. The objective described as ‘‘the great imitator.’’ To render the situation of this study was to assess the contribution of immunohisto- more complex HIV infection can be associated with 1–4 chemistry for the identification and localization of Treponema syphilis and can affect its presentation and progression. pallidum on the skin. We retrieved from our files 12 paraffin- At the histologic examination, the diagnostic clues embedded biopsies of skin lesions, which had posed diagnostic for syphilis are not always straightforward. For instance, problems in the past. Only a serologic test had proven that the

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jan 1, 2009

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