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Significance of Loss of Heterozygosity in Predicting Axillary Lymph Node Metastasis of Invasive Ductal Carcinoma of the Breast

Significance of Loss of Heterozygosity in Predicting Axillary Lymph Node Metastasis of Invasive... RESEARCH ARTICLE Significance of Loss of Heterozygosity in Predicting Axillary Lymph Node Metastasis of Invasive Ductal Carcinoma of the Breast Xiaoqi Lin, MD, PhD,* Bing Zhu, MD, PhD,* Sydney D. Finkelstein, MD,w Reda S. Saad, MD,z Andrea Snitchler, DO,y and Jan F. Silverman, MDy INTRODUCTION Abstract: Invasive ductal carcinoma (IDC) of breast metastatic Invasive ductal carcinoma (IDC) of the breast is a to axillary lymph node (ALN) is a critical factor in determining malignancy characterized by accumulation of multiple stage and is a strong predictor of disease prognosis and survival. genetic alterations that control cell cycle, invasion, We studied ALN metastasis using a combined histopathologic/ 1,2 metastasis, etc, although the molecular basis of IDC molecular approach to gain insights into the pathobiology tumorigenesis and metastasis is still not completely implications. Fourteen patients with IDC with positive ALN understood. IDC staging remains the strongest clinically and 19 with negative ALN were retrieved. Analysis of 17 used predictor of disease aggressiveness and survival. The polymorphic microsatellite repeat markers targeting 1p34-36, well-accepted prognostic factors related to breast cancer 3p24-26, 5q23, 9p21, 10q23, 17p13, 17q12, 17q21, 21q22, and are lymph node status, tumor size, histopathologic 22q13 was carried out in DNA isolated from http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Significance of Loss of Heterozygosity in Predicting Axillary Lymph Node Metastasis of Invasive Ductal Carcinoma of the Breast

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References (53)

Copyright
Copyright © 2011 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e31822afce2
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Significance of Loss of Heterozygosity in Predicting Axillary Lymph Node Metastasis of Invasive Ductal Carcinoma of the Breast Xiaoqi Lin, MD, PhD,* Bing Zhu, MD, PhD,* Sydney D. Finkelstein, MD,w Reda S. Saad, MD,z Andrea Snitchler, DO,y and Jan F. Silverman, MDy INTRODUCTION Abstract: Invasive ductal carcinoma (IDC) of breast metastatic Invasive ductal carcinoma (IDC) of the breast is a to axillary lymph node (ALN) is a critical factor in determining malignancy characterized by accumulation of multiple stage and is a strong predictor of disease prognosis and survival. genetic alterations that control cell cycle, invasion, We studied ALN metastasis using a combined histopathologic/ 1,2 metastasis, etc, although the molecular basis of IDC molecular approach to gain insights into the pathobiology tumorigenesis and metastasis is still not completely implications. Fourteen patients with IDC with positive ALN understood. IDC staging remains the strongest clinically and 19 with negative ALN were retrieved. Analysis of 17 used predictor of disease aggressiveness and survival. The polymorphic microsatellite repeat markers targeting 1p34-36, well-accepted prognostic factors related to breast cancer 3p24-26, 5q23, 9p21, 10q23, 17p13, 17q12, 17q21, 21q22, and are lymph node status, tumor size, histopathologic 22q13 was carried out in DNA isolated from

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Mar 1, 2012

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