Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
case reports Severe Lactic Acidosis Complicated by Insulin-Resistant Hyperosmolar Hyperglycemic Syndrome in a Patient With Metastatic Breast Cancer Undergoing AKT-Inhibitor Therapy 1 2 3 4 4 Maria I. Stamou, MD, PhD ; Christopher Chen, MD ; Seth A. Wander, MD ; Jeffrey G. Supko, PhD ; Dejan Juric, MD ; 3 5,6 Aditya Bardia, MD ; and Deborah J. Wexler MD MSc JCO Precis Oncol 6:e2100428. © 2022 by American Society of Clinical Oncology Introduction (coefficient of variation [CV], 2%). By comparison, the geometric mean steady state trough plasma concen- The serine/threonine–phosphoinositide 3-kinase pro- tration of ipatasertib in four other patients enrolled in tein B mammalian target rapamycin (PI3K-PKB/AKT/ the same arm of the study was 44.2 ng/mL (CV, 57%). mTOR-PAM) pathway regulates the cell proliferation. Given that she had not received any drug for 9 days, PAM kinases are overexpressed in malignancies, her residual plasma concentration of ipatasertib on prompting the development of PAM inhibitors (PAMi) C1D15 (16.7 ng/mL) was much higher than expected. as targeted cancer therapy. Apart from its important As calculated using the previously reported value of role in cell survival, the PI3K-AKT pathway’s role in 45.8 hours for the geometric mean apparent half-life of
JCO: Precision Oncology – Wolters Kluwer Health
Published: Jun 14, 2022
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.