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- ISSN
- 1556-0864
- DOI
- 10.1097/JTO.0b013e3181ae2844
- pmid
- 19620934
- Publisher site
- See Article on Publisher Site
Abstract
ORIGINAL ARTICLE Serum Osteopontin Levels are Highly Prognostic for Survival in Advanced Non-small Cell Lung Cancer Results from JMTO LC 0004 Shun-Ichi Isa, MS,* Tomoya Kawaguchi, MD,* Satoshi Teramukai, PhD,† Koichi Minato, MD,‡ Yoshinobu Ohsaki, MD,§ Kazuhiko Shibata, MD, Toshirou Yonei, MD,¶ Kenji Hayashibara, MD,# Masanori Fukushima, MD,† Masaaki Kawahara, MD,* Kiyoyuki Furuse, MD,** and Philip C. Mack, PhD†† high bFGF levels correlated with better OS (HR 0.53; 95% CI, Background: The Japan-Multinational Trial Organization (JMTO) 0.31– 0.90; p 0.018). lung cancer (LC) 0003 was a prospective randomized phase III trial Conclusion: Consistent with the findings from SWOG 0003, low investigating advanced non-small cell lung cancer comparing pac- OPN serum levels were significantly associated with a favorable litaxel (P) plus carboplatin (C) versus vinorelbine (V), gemcitabine prognosis in the JMTO LC 0004. Additionally, high bFGF levels (G) followed by docetaxel (D). This trial was conducted with were associated with improved survival. Southwest Oncology Group (SWOG) 0003 using a common arm of Key Words: Non-small cell lung cancer, Osteopontin, bFGF, PC. An analysis of SWOG 0003 samples showed that low osteopon- Correlative study. tin (OPN) plasma levels were highly prognostic for a better out- come. We performed an
Journal
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Sep 1, 2009